MGP Database

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MGP006373

UniProt Annotations

Entry Information
Gene NameArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Protein EntryARAP1_HUMAN
UniProt IDQ96P48
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=6; IsoId=Q96P48-6; Sequence=Displayed; Name=1; IsoId=Q96P48-1; Sequence=VSP_036607, VSP_036608; Name=2; IsoId=Q96P48-2; Sequence=VSP_036607, VSP_036608, VSP_000311; Name=3; IsoId=Q96P48-3; Sequence=VSP_000311; Name=4; IsoId=Q96P48-4; Sequence=VSP_015000; Note=No experimental confirmation available.; Name=5; IsoId=Q96P48-5; Sequence=VSP_014998, VSP_015001, VSP_000311; Note=No experimental confirmation available.; Name=7; IsoId=Q96P48-7; Sequence=VSP_015000, VSP_043530, VSP_000311; Note=No experimental confirmation available.;
FunctionPhosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250}.
InteractionP27958:- (xeno); NbExp=3; IntAct=EBI-710003, EBI-8753518; O00220:TNFRSF10A; NbExp=4; IntAct=EBI-710003, EBI-518861; P12956:XRCC6; NbExp=2; IntAct=EBI-710003, EBI-353208;
Sequence CautionSequence=BAA34502.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
SimilarityContains 1 Ras-associating domain. {ECO:0000255|PROSITE-ProRule:PRU00166}.
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
SimilarityContains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
SimilarityContains 4 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
SubunitInteracts with TNFRSF10A. {ECO:0000269|PubMed:18165900}.
Tissue SpecificityDetected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. {ECO:0000269|PubMed:11804590}.
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