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MGP006439

UniProt Annotations

Entry Information
Gene Namedelta(4)-desaturase, sphingolipid 2
Protein EntryDEGS2_HUMAN
UniProt IDQ6QHC5
SpeciesHuman
Comments
Comment typeDescription
FunctionBifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. {ECO:0000250|UniProtKB:Q8R2F2}.
InductionUp-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9. {ECO:0000269|PubMed:15063729}.
PathwayMembrane lipid metabolism; sphingolipid biosynthesis.
SimilarityBelongs to the fatty acid desaturase family. DEGS subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R2F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8R2F2}.
Tissue SpecificityHighly expressed in skin, intestine and kidney. {ECO:0000269|PubMed:15063729}.
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