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MGP006629

Ontology/Pathway Information

Entrez Gene ID148022
Gene Nametoll-like receptor adaptor molecule 1
Gene Symbol TICAM1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0010008 TAS:ReactomeCendosome membrane
GO:0097342 IDA:UniProtKBCripoptosome
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004871 IMP:UniProtKBFsignal transducer activity
GO:0097190 IEA:EnsemblPapoptotic signaling pathway
GO:0051607 IEA:UniProtKB-KWPdefense response to virus
GO:0007249 TAS:ReactomePI-kappaB kinase/NF-kappaB signaling
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0002281 IEA:EnsemblPmacrophage activation involved in immune response
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0030890 IEA:EnsemblPpositive regulation of B cell proliferation
GO:0045080 IEA:EnsemblPpositive regulation of chemokine biosynthetic process
GO:0043123 IMP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045359 IEA:EnsemblPpositive regulation of interferon-beta biosynthetic process
GO:0032755 IEA:EnsemblPpositive regulation of interleukin-6 production
GO:0032816 IEA:EnsemblPpositive regulation of natural killer cell activation
GO:0051092 IEA:EnsemblPpositive regulation of NF-kappaB transcription factor activity
GO:0045429 IEA:EnsemblPpositive regulation of nitric oxide biosynthetic process
GO:0032092 IEA:EnsemblPpositive regulation of protein binding
GO:0031398 IEA:EnsemblPpositive regulation of protein ubiquitination
GO:0032760 IEA:EnsemblPpositive regulation of tumor necrosis factor production
GO:0043496 IEA:EnsemblPregulation of protein homodimerization activity
GO:0043330 IMP:MGIPresponse to exogenous dsRNA
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25148Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_25374IKK complex recruitment mediated by RIP1
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_6809MyD88-independent cascade
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_25351TRAF6 mediated induction of TAK1 complex
REACT_150361TRIF-mediated programmed cell death
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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