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MGP006733

UniProt Annotations

Entry Information

Gene Name	short chain dehydrogenase/reductase family 16C, member 5
Protein Entry	RDHE2_HUMAN
UniProt ID	Q8N3Y7
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N3Y7-1; Sequence=Displayed; Name=2; IsoId=Q8N3Y7-2; Sequence=VSP_028389;
Catalytic Activity	All-trans-retinol-[cellular-retinol-binding- protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding- protein] + NADH.
Function	Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. {ECO:0000269\|PubMed:18926804}.
Pathway	Cofactor metabolism; retinol metabolism.
Sequence Caution	Sequence=BAB71545.1; Type=Frameshift; Positions=226; Evidence={ECO:0000305};
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung. {ECO:0000269\|PubMed:12372410}.