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MGP007078

UniProt Annotations

Entry Information
Gene NameTMEM189-UBE2V1 readthrough
Protein EntryUB2V1_HUMAN
UniProt IDQ13404
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=3; Synonyms=Isoform 2; IsoId=Q13404-4; Sequence=Displayed; Name=1; Synonyms=CROC-1B, UEV-1B, Isoform 4; IsoId=Q13404-1; Sequence=VSP_038034; Note=Ref.2 (AAC02755) sequence is in conflict in positions: 71:SPHETYFCITT->WPTSSAQCYSP. {ECO:0000305}; Name=2; Synonyms=CROC-1A, UEV-1A; IsoId=Q13404-2; Sequence=VSP_038033; Name=4; Synonyms=UEV-1As; IsoId=Q13404-6; Sequence=VSP_038032, VSP_038036; Name=5; Synonyms=Isoform 3; IsoId=Q13404-7; Sequence=VSP_038035; Name=6; IsoId=Q13404-8; Sequence=VSP_044818; Note=No experimental confirmation available.;
FunctionHas no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:9305758, ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9580084, ECO:0000269|PubMed:9705497}.
InductionDown-regulated during differentiation of cultured colon adenocarcinoma cells. {ECO:0000269|PubMed:9418904}.
InteractionQ6ZNA4:RNF111; NbExp=2; IntAct=EBI-1050671, EBI-2129175; P61088:UBE2N; NbExp=18; IntAct=EBI-1050671, EBI-1052908; P98170:XIAP; NbExp=3; IntAct=EBI-1050671, EBI-517127; Q8ND25:ZNRF1; NbExp=2; IntAct=EBI-1050671, EBI-2129250;
MiscellaneousIn human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.
Sequence CautionSequence=AAH08944.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC16955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the ubiquitin-conjugating enzyme family. {ECO:0000255|PROSITE-ProRule:PRU00388}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:9305758}. Note=Excluded from the nucleolus.
SubunitHeterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:16307917}.
Tissue SpecificityHighly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. {ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9705497}.
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