MGP Database

MGP007290

Record overview

MGPD ID	MGP007290
Gene ID	100302736
Species	Homo sapiens (Human)
Gene Name	TMED7-TICAM2 readthrough
Gene Symbol	TMED7-TICAM2
Alternate names	TRAM adaptor with GOLD domain; TMED7-TICAM2 read-through transcript;
Chromosome	5
Map Location	chromosome:5
Summary	This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
Orthologs	View orthologs and multiple alignments for TMED7-TICAM2

Proteins

TRAM adaptor with GOLD domain isoform 1 precursor

Refseq ID:	NP_001157940
Protein GI:	256985100
UniProt ID:	Q86XR7
mRNA ID:	NM_001164468
Length:	404
RefSeq Status:

MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTA
SKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWHSVDTSPGYHE
SDSKKSEDLSLCNVAEHSNTTEGPTGKQEGAQSVEEMFEEEAEEEVFLKFVILHAEDDTDEALRVQNLLQDDFGIKPGIIFAEMPCGRQHLQNLDDAVNG
SAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPLNNPLPRERTPFALQTINALEEESRGFPTQVERIFQESVYKTQQTIWKETRNMVQR
QFIA

TRAM adaptor with GOLD domain isoform 2 precursor
`sig_peptide: 1..34 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3499 peptide sequence: MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGA`

Refseq ID:	NP_001157941
Protein GI:	256985102
UniProt ID:	Q86XR7
mRNA ID:	NM_001164469
Length:	188
RefSeq Status:

`MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTA SKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAY`

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3499
peptide sequence: 
MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGA

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3499
peptide sequence: 
MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGA