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MGP007293

UniProt Annotations

Entry Information
Gene NameARPC4-TTLL3 readthrough
Protein EntryARPC4_HUMAN
UniProt IDP59998
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P59998-1; Sequence=Displayed; Name=2; IsoId=P59998-2; Sequence=VSP_046151; Note=No experimental confirmation available.; Name=3; IsoId=P59998-3; Sequence=VSP_046150; Note=No experimental confirmation available.; Name=4; IsoId=P59998-4; Sequence=VSP_046753; Note=No experimental confirmation available. Gene prediction based on EST data.;
FunctionFunctions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
Sequence CautionSequence=AAH12596.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the ARPC4 family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9359840}.
SubunitComponent of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
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