Invitation to Deposit Metabolomics Experimental Data
The Metabolomics Consortium Data Repository and Coordinating Center (DRCC) is now accepting metabolomics data for small and large studies on cells, tissues and organisms from NIH grantees/projects via the Metabolomics Workbench. We can accommodate a variety of metabolite analyses, including, but not limited to MS and NMR. The Metabolomics Workbench also provides a suite of tools for analysis and visualization of the data.
Invitation to Nominate Compounds for Synthesis
As part of the NIH Common Fund's Metabolomics Program, the Metabolite Standards Synthesis Core (MSSC) aims to provide metabolomics researchers with high quality metabolite standards.
We invite scientists to nominate compounds for synthesis. Nominated compounds will be reviewed by the NIH Common Fund’s executive committee, and prioritized for synthesis.
Metabolomics Workbench HighlightsIdentification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics
In this project from the Mayo clinic, researchers examined global metabolic changes in both plasma and cerebrospinal fluid (CSF) from individuals representing the spectrum of Alzheimer’s Disease - ranging from cognitively normal (CN) to mild cognitive impairment (MCI) to Alzheimer’s Disease (AD). Data produced from their non-targeted metabolomics approach, point to alterations in a number of metabolic pathways, and pave the way for identification of novel therapeutic targets.
Reference: Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One. 2013 May 20;8(5):e63644.
Network motifs provide signatures that characterize metabolism
Shellman ER, Burant CF, Schnell S
Mol Biosyst. 2013 Mar;9(3):352-60
Isotopic ratio outlier analysis global metabolomics of Caenorhabditis elegans.
Stupp GS, Clendinen CS, Ajredini R, Szewc MA, Garrett T, Menger RF, Yost RA, Beecher C, Edison AS
Anal Chem. 2013 Dec 17;85(24):11858-65. doi: 10.1021/ac4025413. Epub 2013 Dec 4.