Summary of Study ST002254
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001442. The data can be accessed directly via it's Project DOI: 10.21228/M8B71S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002254 |
Study Title | Maternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle |
Study Summary | Maternal obesity (MO) during pregnancy is linked to increased and premature risk of age-related metabolic diseases in the offspring. However, the underlying molecular mechanisms still remain not fully understood. Using a well-established baboon model of MO, we analyzed tissue biopsies and plasma samples obtained from post-pubertal offspring (3-6.5y at sample collection) of MO mothers (n=19) and from control animals born to mothers fed a standard diet (CON, n=13). All offspring ate normal chow diet after weaning. With an untargeted gas chromatography-mass spectrometry metabolomics profiling, we quantified a total of 351 liver, 316 skeletal muscle and 423 plasma metabolites. We found 58 metabolites significantly altered in liver and 46 in skeletal muscle of MO offspring, including 8 metabolites shared between both tissues. Male and female-specific metabolites in opposite direction of change were found in liver and skeletal muscle of MO offspring. Several tissue-specific and 4 shared metabolic pathways were identified from these dysregulated metabolites. Interestingly, none of the tissue-specific metabolic alterations reflected in plasma. Our results identify tissue metabolites and pathways in post-pubertal MO offspring in a sex-specific manner. |
Institute | Wake Forest School of Medicine |
Last Name | Ampong |
First Name | Isaac |
Address | Center for Precision Medicine, Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University, Winston-Salem, North Carolina, United States |
iampong@wakehealth.edu | |
Phone | 3367162091 |
Submit Date | 2022-08-02 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzML |
Analysis Type Detail | GC-MS |
Release Date | 2022-08-31 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Papio hamadryas (Factor headings shown in green)
mb_sample_id | local_sample_id | Sample type |
---|---|---|
SA216995 | L34776 | LIVER |
SA216996 | L34832 | LIVER |
SA216997 | L34210 | LIVER |
SA216998 | L34163 | LIVER |
SA216999 | L34155 | LIVER |
SA217000 | L34867 | LIVER |
SA217001 | L34165 | LIVER |
SA217002 | L34913 | LIVER |
SA217003 | L35315 | LIVER |
SA217004 | L36492 | LIVER |
SA217005 | L34984 | LIVER |
SA217006 | L34953 | LIVER |
SA217007 | L33895 | LIVER |
SA217008 | L34952 | LIVER |
SA217009 | L32650 | LIVER |
SA217010 | L34906 | LIVER |
SA217011 | L32927 | LIVER |
SA217012 | L34156 | LIVER |
SA217013 | L34160 | LIVER |
SA217014 | L32862 | LIVER |
SA217015 | L32798 | LIVER |
SA217016 | L33893 | LIVER |
SA217017 | L32771 | LIVER |
SA217018 | L34172 | LIVER |
SA217019 | L34166 | LIVER |
SA217020 | L33857 | LIVER |
SA217021 | L33873 | LIVER |
SA217022 | L33601 | LIVER |
SA217023 | L33472 | LIVER |
SA217024 | L34777 | LIVER |
SA217025 | L32732 | LIVER |
SA217026 | L33308 | LIVER |
SA217027 | LQC22 | NIST PLASMA |
SA217028 | LQC11 | NIST PLASMA |
SA217029 | LQC33 | NIST PLASMA |
SA217030 | LQC66 | NIST PLASMA |
SA217031 | LQC44 | NIST PLASMA |
SA217032 | LQC55 | NIST PLASMA |
SA217033 | P34832 | PLASMA |
SA217034 | P34867 | PLASMA |
SA217035 | P34776 | PLASMA |
SA217036 | P34210 | PLASMA |
SA217037 | P34906 | PLASMA |
SA217038 | P34777 | PLASMA |
SA217039 | P34952 | PLASMA |
SA217040 | P36492 | PLASMA |
SA217041 | P35315 | PLASMA |
SA217042 | P34984 | PLASMA |
SA217043 | P34953 | PLASMA |
SA217044 | P34913 | PLASMA |
SA217045 | P34172 | PLASMA |
SA217046 | P32732 | PLASMA |
SA217047 | P32650 | PLASMA |
SA217048 | P33472 | PLASMA |
SA217049 | P32771 | PLASMA |
SA217050 | P32862 | PLASMA |
SA217051 | P34166 | PLASMA |
SA217052 | P33308 | PLASMA |
SA217053 | P32927 | PLASMA |
SA217054 | P33601 | PLASMA |
SA217055 | P32798 | PLASMA |
SA217056 | P34160 | PLASMA |
SA217057 | P34163 | PLASMA |
SA217058 | P33857 | PLASMA |
SA217059 | P34165 | PLASMA |
SA217060 | P34156 | PLASMA |
SA217061 | P33873 | PLASMA |
SA217062 | P33893 | PLASMA |
SA217063 | P33895 | PLASMA |
SA217064 | P34155 | PLASMA |
SA217065 | 34906 | SKELETAL MUSCLE |
SA217066 | 34867 | SKELETAL MUSCLE |
SA217067 | 34777 | SKELETAL MUSCLE |
SA217068 | 34776 | SKELETAL MUSCLE |
SA217069 | 34832 | SKELETAL MUSCLE |
SA217070 | 35315 | SKELETAL MUSCLE |
SA217071 | 36492 | SKELETAL MUSCLE |
SA217072 | 34210 | SKELETAL MUSCLE |
SA217073 | 34984 | SKELETAL MUSCLE |
SA217074 | 34953 | SKELETAL MUSCLE |
SA217075 | 34952 | SKELETAL MUSCLE |
SA217076 | 34913 | SKELETAL MUSCLE |
SA217077 | 34155 | SKELETAL MUSCLE |
SA217078 | 32927 | SKELETAL MUSCLE |
SA217079 | 33308 | SKELETAL MUSCLE |
SA217080 | 33472 | SKELETAL MUSCLE |
SA217081 | 32862 | SKELETAL MUSCLE |
SA217082 | 32798 | SKELETAL MUSCLE |
SA217083 | 32650 | SKELETAL MUSCLE |
SA217084 | 32732 | SKELETAL MUSCLE |
SA217085 | 32771 | SKELETAL MUSCLE |
SA217086 | 33601 | SKELETAL MUSCLE |
SA217087 | 33857 | SKELETAL MUSCLE |
SA217088 | 34163 | SKELETAL MUSCLE |
SA217089 | 34165 | SKELETAL MUSCLE |
SA217090 | 34166 | SKELETAL MUSCLE |
SA217091 | 34160 | SKELETAL MUSCLE |
SA217092 | 34156 | SKELETAL MUSCLE |
SA217093 | 33873 | SKELETAL MUSCLE |
SA217094 | 33893 | SKELETAL MUSCLE |