Summary of Study ST000724
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000521. The data can be accessed directly via it's Project DOI: 10.21228/M89X00 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000724 |
| Study Title | Red squirrels age related changes |
| Study Type | MS analysis |
| Study Summary | Metabolomics has recently been used to document age-related changes in key metabolic pathways in laboratory animals and as a biomarker to predict age. We study the ecology, evolution, behavior, and physiology of wild North American red squirrels where we are able to follow individual squirrels across their lifetime from birth until death. We are beginning to document aging in this natural population and are interested in understanding whether there is a signature of aging using metabolomics. We collected plasma samples from the oldest female and male squirrels in our study population and also from an equivalent number of younger squirrels. We will use an untargeted approach to provide an assessment of what metabolites differ among very old and young squirrels. The aim of these analyses is to allow us to identify if the same metabolites that have been identified as biomarkers of advanced age from laboratory mice are also biomarkers of advanced age in red squirrels. After we complete these untargeted analyses, we aim to develop a metabolomics panel for this species so that we can use a more targeted approach to assess how the metabolic profiles of specific pathways (glucose/fatty acid metabolism, redox homeostasis) change with age in offspring exposed to increased perinatal stress in our study species. |
| Institute | University of Michigan |
| Department | Biomedical Research Core Facilities |
| Laboratory | Metabolomics core |
| Last Name | Kachman |
| First Name | Maureen |
| Address | 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 |
| mkachman@med.umich.edu | |
| Phone | (734) 232-8175 |
| Submit Date | 2017-06-19 |
| Num Groups | 6 |
| Total Subjects | 33 |
| Study Comments | Metabolomics has recently been used to document age-related changes in key metabolic pathways in laboratory animals and as a biomarker to predict age. We study the ecology, evolution, behavior, and physiology of wild North American red squirrels where we are able to follow individual squirrels across their lifetime from birth until death. We are beginning to document aging in this natural population and are interested in understanding whether there is a signature of aging using metabolomics. |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-12-06 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Animal; Subject species: Tamiasciurus hudsonicus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Age Category |
|---|---|---|
| SA040688 | S00026266 | Old | Sex of individual:Female |
| SA040689 | S00026261 | Old | Sex of individual:Female |
| SA040690 | S00026258 | Old | Sex of individual:Female |
| SA040691 | S00026260 | Old | Sex of individual:Female |
| SA040692 | S00026264 | Old | Sex of individual:Female |
| SA040693 | S00026242 | Old | Sex of individual:Female |
| SA040694 | S00026263 | Old | Sex of individual:Female |
| SA040695 | S00026262 | Old | Sex of individual:Male |
| SA040696 | S00026257 | Old | Sex of individual:Male |
| SA040697 | S00026234 | Old | Sex of individual:Male |
| SA040698 | S00026265 | Old | Sex of individual:Male |
| SA040699 | S00026259 | Old | Sex of individual:Male |
| SA040700 | S00026255 | Old | Sex of individual:Male |
| SA040701 | S00026239 | Old | Sex of individual:Male |
| SA040702 | S00026241 | Old | Sex of individual:Male |
| SA040703 | S00026236 | Old | Sex of individual:Male |
| SA040704 | S00026249 | Old | Sex of individual:Young |
| SA040705 | S00026253 | Unknown | Sex of individual:Male |
| SA040706 | S00026256 | Young | Sex of individual:Female |
| SA040707 | S00026247 | Young | Sex of individual:Female |
| SA040708 | S00026238 | Young | Sex of individual:Female |
| SA040709 | S00026237 | Young | Sex of individual:Female |
| SA040710 | S00026245 | Young | Sex of individual:Female |
| SA040711 | S00026251 | Young | Sex of individual:Female |
| SA040712 | S00026252 | Young | Sex of individual:Female |
| SA040713 | S00026254 | Young | Sex of individual:Female |
| SA040714 | S00026250 | Young | Sex of individual:Male |
| SA040715 | S00026240 | Young | Sex of individual:Male |
| SA040716 | S00026235 | Young | Sex of individual:Male |
| SA040717 | S00026243 | Young | Sex of individual:Male |
| SA040718 | S00026244 | Young | Sex of individual:Male |
| SA040719 | S00026246 | Young | Sex of individual:Male |
| SA040720 | S00026248 | Young | Sex of individual:Male |
| Showing results 1 to 33 of 33 |
