Summary of Study ST003186

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001807. The data can be accessed directly via it's Project DOI: 10.21228/M84Q6N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003186
Study TitleUntargeted plasma metabolomics on mouse bloodstream infection model with cecal slurry
Study SummaryAs part of our pipeline to identify microbial metabolites in bloodstream infections, we performed untargeted metabolomics on plasma from male B6 mice that developed bloodstream infections as result of an injection of cecal slurry. More specifically, we harvested plasma 24hrs after IP injection of PBS, heat killed cecal slurry, or live cecal slurry. The comparison of heat killed cecal slurry vs live cecal slurry allows us to tease apart metabolite alterations due to the host response to an infectious insult vs metabolite changes produced by live bacteria. For this analysis, we specifically focused on the metabolites significantly altered in our human cohort (PR001807). Metabolites that were altered in this model were then examined in microbial culture experiments
Institute
Harvard University
Last NameMayers
First NameJared
Address12 Oxford St Conant 200S Cambridge, MA 02138
Emailjrmayers@gmail.com
Phone4259417747
Submit Date2024-04-26
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-05-06
Release Version1
Jared Mayers Jared Mayers
https://dx.doi.org/10.21228/M84Q6N
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Factor Sample source
SA34681124hr_10Control Plasma
SA34681224hr_1Control Plasma
SA34681324hr_13Control Plasma
SA34681424hr_7Control Plasma
SA34681524hr_16Control Plasma
SA34681624hr_19Control Plasma
SA34681724hr_4Control Plasma
SA34681824hr_22Control Plasma
SA34681924hr_23Heat Killed Plasma
SA34682024hr_14Heat Killed Plasma
SA34682124hr_17Heat Killed Plasma
SA34682224hr_11Heat Killed Plasma
SA34682324hr_2Heat Killed Plasma
SA34682424hr_5Heat Killed Plasma
SA34682524hr_8Heat Killed Plasma
SA34682624hr_24Live Plasma
SA34682724hr_3Live Plasma
SA34682824hr_12Live Plasma
SA34682924hr_6Live Plasma
Showing results 1 to 19 of 19
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