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MB Sample ID: SA096569
Local Sample ID: | 20190326_BJJ_Acyl_carnitines_Sample_3_HBS |
Subject ID: | SU001406 |
Subject Type: | Invertebrate |
Subject Species: | Caenorhabditis elegans |
Taxonomy ID: | 6239 |
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Treatment:
Treatment ID: | TR001421 |
Treatment Summary: | Parental exposure to environmental stress can program adaptive changes in offspring in diverse organisms (1–4). The mechanisms by which parental exposure to environmental stresses can program predictive adaptive responses in offspring remain almost completely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a natural pathogen of the nematode Caenorhabditis elegans and that parental exposure of C. elegans to P. vranovensis promotes offspring resistance to infection. This adaptation can be transmitted transgenerationally such that infection of adults can enhance the immunity of their descendants four generations later. We find that parental infection by P. vranovensis results in increased expression of the cysteine synthases CYSL-1 and CYSL-2 and the regulator of hypoxia inducible factor RHY-1 in progeny, that the expression of these three genes in offspring is required for adaptation to P. vranovensis, and that the expression of these genes is regulated by the WD40 repeat protein WDR-23. |