Summary of project PR000811
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000811. The data can be accessed directly via it's Project DOI: 10.21228/M8VD62 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000811 |
| Project DOI: | doi: 10.21228/M8VD62 |
| Project Title: | 12-LOX metabolites in cold adaptation |
| Project Summary: | The goal of this project is to understand the role of the enzyme 12-lipoxygenase in the adaptive thermogenesis. We found this enzyme is activated by cold stimulation, then producing lipid metabolites in adipose tissue and releasing them into the circulation to regulate fuel utilisation and thermogenic pathways required for the cold adaptation. |
| Institute: | Joslin Diabetes Center |
| Department: | Integrative Physiology and Metabolism |
| Laboratory: | Yu-Hua Tseng lab |
| Last Name: | Leiria |
| First Name: | Luiz |
| Address: | One Joslin Place, Boston, MA-USA, 02215 |
| Email: | luiz.leiri@joslin.harvard.edu |
| Phone: | 1 6173091967 |
Summary of all studies in project PR000811
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001206 | Effects of cold exposure on serum lipidomic in mice | Mus musculus | Joslin Diabetes Center | MS | 2019-07-17 | 1 | 33 | Uploaded data (162.7M)* |
| ST001207 | Lipidomics in the serum of cold exposed mice treated with 12-LOX inhibitor LOXBlock-1 | Mus musculus | Joslin Diabetes Center | MS | 2019-07-17 | 1 | 19 | Uploaded data (258.8M)* |
| ST001213 | Serum lipidomic profile of cold-exposed Ucp1cre/12-LOX KO mice | Mus musculus | Joslin Diabetes Center | MS | 2019-09-23 | 1 | 24 | Uploaded data (580.5M)* |
| ST001214 | Lipidommics in the serum of human subjects | Homo sapiens | Joslin Diabetes Center | MS | 2019-09-23 | 1 | 60 | Uploaded data (626.4M)* |
| ST001215 | Effect of Mirabegron Treatment on serum lipidome | Homo sapiens | Joslin Diabetes Center | MS | 2019-09-23 | 1 | 22 | Uploaded data (189.1M)* |
