Summary of project PR001866
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001866. The data can be accessed directly via it's Project DOI: 10.21228/M8HM8S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001866 |
| Project DOI: | doi: 10.21228/M8HM8S |
| Project Title: | Tissue Lipidomic Profiling for Detection of Non-Small Cell Lung Cancer |
| Project Type: | non-targeted lipidomics analysis |
| Project Summary: | NSCLC is the most prevalent type of lung cancer with high mortality rates. In this study, we performed nontargeted lipidomic profiling study of 230 tissue samples from 79 NSCLC patients with adenocarcinoma (AC) or squamous cell carcinoma (SCC) using UPLC-HRMS. oPLS-DA classification models enabled discrimination of tumor from adjacent noncancerous tissue (ANT) and distant noncancerous tissue (DNT) samples in NSCLC and AC with good accuracies (94.1 and 92.0%), sensitivities (93.8 and 91.1%), and specificities (94.2 and 92.5%) using 7 and 8 discriminant compounds, respectively. The discriminant feature panels were verified by external validation sets, revealing characteristic lipid signatures associated with NSCLC and showing prospects for entering the next evaluation stage of biomarker discovery for NSCLC detection and subtyping. |
| Institute: | OUC |
| Department: | Department of Medicine and Pharmacy |
| Laboratory: | Analytical chemistry |
| Last Name: | Zhang |
| First Name: | Jie |
| Address: | No. 5 Yushan Road, Qingdao, Shandong, China |
| Email: | zhangjieqau@163.com |
| Phone: | 17806277823 |
| Funding Source: | OUC |
| Project Comments: | OUC |
| Publications: | OUC |
| Contributors: | OUC |
Summary of all studies in project PR001866
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002996 | Tissue Lipidomic Profiling for Detection of Non-Small Cell Lung Cancer | Homo sapiens | OUC | MS* | 2023-12-27 | 1 | 230 | Uploaded data (11.2G)* |
