Summary of study ST000450

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Study IDST000450
Study TitleMetabolic features of chronic fatigue syndrome
Study TypePlasma metabolomic profiling
Study SummaryThis targeted metabolomic analysis was performed on plasma samples from 39 normal controls (n=18 men and 21 women) and 45 subjects ((n = 22 men and 23 women) who met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria.
InstituteUniversity of California, San Diego
DepartmentThe Mitochondrial and Metabolic Disease Center
Last NameNaviaux
First NameRobert
Address214 Dikinson Street, CTF-C102, San Diego, CA, 92103
Emailmaviaux@ucsd.edu
Phone619-993-2904
Submit Date2016-08-11
Num Groups2 groups for men (control and CFS) and 2 groups for women (control and CFS)
Total Subjects84
Release Date2016-12-22
Release Version1

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Project:

Project ID:PR000348
Project DOI:doi: 10.21228/M82K58
Project Title:Metabolic features of chronic fatigue
Project Type:Human plasma
Project Summary:More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using these methods. Forty-five subjects (n = 22 men and 23 women) met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. We targeted 612 metabolites in plasma from 63 biochemical pathways by hydrophilic interaction liquid chromatography, electrospray ionization, and tandem mass spectrometry in a single-injection method. Our data show that despite the heterogeneity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statistically robust, and chemically similar to the evolutionarily conserved persistence response to environmental stress known as dauer.
Institute:University of California, San Diego
Department:The Mitochondrial and Metabolic Disease Center
Last Name:Naviaux
First Name:Robert
Address:214 Dikinson Street, CTF-C102, San Diego, CA, 92103
Email:maviaux@ucsd.edu
Phone:(619) 993-2904
Funding Source:UCSD Christini Fund,The Wright Family Foundation,The Lennox Foundation, The It Takes Guts Foundation, The UCSD Mitochondrial Disease Research Fund
Publications:PNAS publication
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