Summary of Study ST001114
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000745. The data can be accessed directly via it's Project DOI: 10.21228/M8CQ42 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001114 |
Study Title | Metabolomics profile of umbilical cord blood is associated with maternal pre-pregnant obesity in a perspective multi-ethnic cohort displaying health disparities |
Study Summary | Maternal obesity has become a growing global health concern that impacts fetal health and subsequently predisposes the offspring to medical conditions later in life. However, the molecular link between abnormal fetal metabolomic profiles and maternal obesity has not yet been fully elucidated. In this study, we report new discoveries from the newborn cord blood metabolomes associated with a case-control maternal obesity cohort, collected from multi-ethnic populations in Hawaii, including rarely reported Native Hawaiian and other Pacific Islanders (NHPI). This cohort displays significant maternal obesity disparities by subjects’ residential area average income and health insurance. An elastic net penalized logistic regression model was constructed to associate cord blood metabolomics and demographic/physiological information to maternal obesity, with accuracy as high as 0.947. We identify 29 metabolites as early-life biomarkers manifesting intrauterine effect of maternal obesity. |
Institute | University of Hawaii |
Department | Epidemiology, Cancer Center |
Last Name | Garmire |
First Name | Lana |
Address | 701 Ilalo Street |
Lgarmire@cc.hawaii.edu | |
Phone | NA |
Submit Date | 2018-03-08 |
Num Groups | 2 |
Total Subjects | 57 |
Raw Data File Type(s) | cdf |
Analysis Type Detail | LC-MS |
Release Date | 2019-01-22 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
Project ID: | PR000745 |
Project DOI: | doi: 10.21228/M8CQ42 |
Project Title: | Cord blood metabolomics are associated with maternal pre-pregnant obesity in a prospective multi-ethnic cohort |
Project Summary: | na |
Institute: | University of Hawaii |
Department: | Epidemiology, Cancer Center |
Last Name: | Garmire |
First Name: | Lana |
Address: | 701 Ilalo Street |
Email: | Lgarmire@cc.hawaii.edu |
Phone: | NA |
Subject:
Subject ID: | SU001159 |
Subject Type: | Human |
Subject Species: | Homo sapiens |
Taxonomy ID: | 9606 |
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Weight |
---|---|---|
SA075916 | MT12 | Normal |
SA075917 | MT45 | Normal |
SA075918 | MT50 | Normal |
SA075919 | MT42 | Normal |
SA075920 | MT39 | Normal |
SA075921 | MT36 | Normal |
SA075922 | MT38 | Normal |
SA075923 | MT51 | Normal |
SA075924 | MT41 | Normal |
SA075925 | MT58 | Normal |
SA075926 | MT73 | Normal |
SA075927 | MT77 | Normal |
SA075928 | MT78 | Normal |
SA075929 | MT68 | Normal |
SA075930 | MT67 | Normal |
SA075931 | MT35 | Normal |
SA075932 | MT64 | Normal |
SA075933 | MT65 | Normal |
SA075934 | MT57 | Normal |
SA075935 | MT44 | Normal |
SA075936 | MT29 | Normal |
SA075937 | MT28 | Normal |
SA075938 | MT27 | Normal |
SA075939 | MT20 | Normal |
SA075940 | MT22 | Normal |
SA075941 | MT23 | Normal |
SA075942 | MT33 | Normal |
SA075943 | MT19 | Normal |
SA075944 | MT15 | Normal |
SA075945 | MT63 | Obese |
SA075946 | MT62 | Obese |
SA075947 | MT66 | Obese |
SA075948 | MT74 | Obese |
SA075949 | MT16 | Obese |
SA075950 | MT13 | Obese |
SA075951 | MT76 | Obese |
SA075952 | MT75 | Obese |
SA075953 | MT18 | Obese |
SA075954 | MT61 | Obese |
SA075955 | MT69 | Obese |
SA075956 | MT24 | Obese |
SA075957 | MT43 | Obese |
SA075958 | MT49 | Obese |
SA075959 | MT26 | Obese |
SA075960 | MT30 | Obese |
SA075961 | MT31 | Obese |
SA075962 | MT32 | Obese |
SA075963 | MT40 | Obese |
SA075964 | MT52 | Obese |
SA075965 | MT53 | Obese |
SA075966 | MT34 | Obese |
SA075967 | MT59 | Obese |
SA075968 | MT25 | Obese |
SA075969 | MT56 | Obese |
SA075970 | MT54 | Obese |
SA075971 | MT55 | Obese |
SA075972 | MT60 | Obese |
Showing results 1 to 57 of 57 |
Collection:
Collection ID: | CO001153 |
Collection Summary: | NA |
Sample Type: | Blood (plasma) |
Treatment:
Treatment ID: | TR001173 |
Treatment Summary: | NA |
Sample Preparation:
Sampleprep ID: | SP001166 |
Sampleprep Summary: | NA |
Combined analysis:
Analysis ID | AN001810 |
---|---|
Analysis type | MS |
Chromatography type | Reversed phase |
Chromatography system | Waters Acquity |
Column | Waters ACQUITY UPLC BEH C18 (1.7um) |
MS Type | ESI |
MS instrument type | Triple quadrupole |
MS instrument name | Waters Xevo TQ-S |
Ion Mode | POSITIVE |
Units | intensity |
Chromatography:
Chromatography ID: | CH001275 |
Instrument Name: | Waters Acquity |
Column Name: | Waters ACQUITY UPLC BEH C18 (1.7um) |
Column Temperature: | 35 |
Flow Rate: | 0.4 ml/min |
Solvent A: | 100% water; 0.1% formic acid |
Solvent B: | 100% acetonitrile; 0.1% formic acid |
Analytical Time: | 6.6 min |
Chromatography Type: | Reversed phase |
MS:
MS ID: | MS001668 |
Analysis ID: | AN001810 |
Instrument Name: | Waters Xevo TQ-S |
Instrument Type: | Triple quadrupole |
MS Type: | ESI |
Ion Mode: | POSITIVE |
Capillary Temperature: | 150 °C |
Capillary Voltage: | 3.9V |
Collision Energy: | 20V |
Collision Gas: | 0.17 mL/Min |
Dry Gas Flow: | 150 L/Hr |
Dry Gas Temp: | 350 °C |