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MB Sample ID: SA098178
| Local Sample ID: | CKD009 |
| Subject ID: | SU001427 |
| Subject Type: | Mammal |
| Subject Species: | Mus musculus |
| Taxonomy ID: | 10090 |
| Genotype Strain: | C57BL6J |
| Age Or Age Range: | 18-20 weeks |
| Weight Or Weight Range: | 20-30g |
| Gender: | Male and female |
| Animal Animal Supplier: | Jackson Laboratories |
| Animal Housing: | 5/cage |
| Animal Light Cycle: | 12h |
| Animal Feed: | Ad libitum. Control mice received custom casein-diet. Chronic kidney disease was induced by supplementing casein-based diet with 0.15% adenine |
| Animal Water: | Ad libitum |
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Treatment:
| Treatment ID: | TR001442 |
| Treatment Summary: | We utilized an established adenine-diet model to induce CKD in mice. Mice were assigned to a casein-based chow diet for 7 days, followed by induction of renal tubular injury by supplementing the diet with 0.2% adenine for 7 days, and were subsequently maintained on a 0.15% adenine diet for 7 more weeks. CKD mice were then placed back on control casein diet for 2 weeks to prior to euthanasia and terminal experiments. Control mice received casein diet for the duration of the study. |
| Animal Anesthesia: | Ketamine/Xylazine |
| Animal Endp Euthanasia: | Ketamine/Xylazine |
