Summary of Study ST002752

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001509. The data can be accessed directly via it's Project DOI: 10.21228/M8N71K This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002752
Study TitleBiomolecular condensates create phospholipid-enriched microenvironments (Part 7 - reversed phase experiment set 2)
Study TypeMetabolomes of in vitro synthesized condensates
Study SummaryProteins and RNA are able to phase separate from the aqueous cellular environment to form sub-cellular compartments called condensates. This process results in a protein-RNA mixture that is chemically distinct from the surrounding aqueous phase. In this project we used mass spectrometry to characterize the metabolomes of condensates. To test this, we prepared mixtures of phase-separated proteins and cellular metabolites and identified metabolites enriched in the condensate phase. These proteins included SARS-CoV-2 nucleocapsid, as well as low complexity domains of MED1 and HNRNPA1. In this sub-study, we examined the metabolomes of the mouse liver samples that were used to conduct the condensate metabolome experiment described above.
Cornell University
DepartmentDepartment of Pharmacology
LaboratoryDr. Samie Jaffrey
Last NameDumelie
First NameJason
Address1300 York Ave, LC-524, New York City, NY
Submit Date2023-06-22
Raw Data AvailableYes
Raw Data File Type(s)xml
Analysis Type DetailLC-MS
Release Date2023-07-10
Release Version1
Jason Dumelie Jason Dumelie application/zip

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Combined analysis:

Analysis ID AN004465 AN004466
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent Model 1290 Infinity II liquid chromatography system Agilent Model 1290 Infinity II liquid chromatography system
Column Cogent Diamond Hydride (150 × 2.1 mm, 4um) Cogent Diamond Hydride (150 × 2.1 mm, 4um)
MS instrument type QTOF QTOF
MS instrument name Bruker Impact HD Bruker Impact HD
Units Ion abundance (max peak height) Ion abundance (max peak height)