Summary of Study ST000405
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000317. The data can be accessed directly via it's Project DOI: 10.21228/M87G7J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000405 |
| Study Title | Metabolomic Profiling in Early Pregnancy using Pre-Diagnostic Sera from Women Who Developed Placental Abruption |
| Study Type | Metabolomics Biocrates Panel |
| Study Summary | Placental abruption (PA) is an ischemic placental disorder that results from the premature separation of the placenta from the wall of the uterus before delivery of the fetus. This disorder is associated with pre-term delivery, fetal death, maternal hemorrhagic shock, and renal failure. Several physiologic disturbances, such as oxidative stress, carbohydrate/fatty acid metabolism, and mitochondrial dysfunction, have been associated with ischemic placental disorder as well as with placental abruption. This preliminary study proposes to identify metabolites associated with incident placental abruption using existing serum and clinical data from a previously studied cohort. Metabolomics analysis will be carried out on maternal serum (51 cases and 51 controls) collected in early pregnancy (early second trimester). |
| Institute | RTI International |
| Department | Discovery Sciences |
| Laboratory | Systems and Translational Sciences |
| Last Name | Burgess |
| First Name | Jason |
| Address | 3040 Cornwallis Rd, RTP, NC, 27609, USA |
| jpb@rti.org | |
| Phone | 919-541-6700 |
| Submit Date | 2016-05-27 |
| Num Groups | 4 |
| Total Subjects | 102 |
| Num Females | 102 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | wiff |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-05-27 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN000645 |
|---|---|
| Analysis type | MS |
| Chromatography type | Reversed phase |
| Chromatography system | Agilent 1100 |
| Column | Agilent Eclipse XDB-C18 (100 x 3.0mm,3.5um) |
| MS Type | ESI |
| MS instrument type | Triple quadrupole |
| MS instrument name | ABI Sciex API 4000 QTrap |
| Ion Mode | UNSPECIFIED |
| Units | area |
Chromatography:
| Chromatography ID: | CH000469 |
| Chromatography Summary: | Biocrates P180 analysis combines a RP for positive mode MS , a flow injection for both pos and neg mode MS |
| Instrument Name: | Agilent 1100 |
| Column Name: | Agilent Eclipse XDB-C18 (100 x 3.0mm,3.5um) |
| Column Pressure: | 30-120 bar for RP and 4-50 bar for FIA |
| Column Temperature: | 50 c fro RP and RT for FIA |
| Flow Rate: | 0.5 ml/min for RP and 0.2 ml/min for FIA |
| Sample Injection: | 10 ul |
| Solvent A: | 100% water; 0.2% formic acid |
| Solvent B: | 100% acetonitrile; 0.2% formic acid for RP; 100% methanol with Biocrates FIa Solvent |
| Chromatography Type: | Reversed phase |
