Summary of Study ST000405

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000317. The data can be accessed directly via it's Project DOI: 10.21228/M87G7J This work is supported by NIH grant, U2C- DK119886.


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Study IDST000405
Study TitleMetabolomic Profiling in Early Pregnancy using Pre-Diagnostic Sera from Women Who Developed Placental Abruption
Study TypeMetabolomics Biocrates Panel
Study SummaryPlacental abruption (PA) is an ischemic placental disorder that results from the premature separation of the placenta from the wall of the uterus before delivery of the fetus. This disorder is associated with pre-term delivery, fetal death, maternal hemorrhagic shock, and renal failure. Several physiologic disturbances, such as oxidative stress, carbohydrate/fatty acid metabolism, and mitochondrial dysfunction, have been associated with ischemic placental disorder as well as with placental abruption. This preliminary study proposes to identify metabolites associated with incident placental abruption using existing serum and clinical data from a previously studied cohort. Metabolomics analysis will be carried out on maternal serum (51 cases and 51 controls) collected in early pregnancy (early second trimester).
RTI International
DepartmentDiscovery Sciences
LaboratorySystems and Translational Sciences
Last NameBurgess
First NameJason
Address3040 Cornwallis Rd, RTP, NC, 27609, USA
Submit Date2016-05-27
Num Groups4
Total Subjects102
Num Females102
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2017-05-27
Release Version1
Jason Burgess Jason Burgess application/zip

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Combined analysis:

Analysis ID AN000645
Analysis type MS
Chromatography type Reversed phase
Chromatography system Agilent 1100
Column Agilent Eclipse XDB-C18 (100 x 3.0mm,3.5um)
MS instrument type Triple quadrupole
MS instrument name ABI Sciex API 4000 QTrap
Units area


Chromatography ID:CH000469
Chromatography Summary:Biocrates P180 analysis combines a RP for positive mode MS , a flow injection for both pos and neg mode MS
Instrument Name:Agilent 1100
Column Name:Agilent Eclipse XDB-C18 (100 x 3.0mm,3.5um)
Column Pressure:30-120 bar for RP and 4-50 bar for FIA
Column Temperature:50 c fro RP and RT for FIA
Flow Rate:0.5 ml/min for RP and 0.2 ml/min for FIA
Sample Injection:10 ul
Solvent A:100% water; 0.2% formic acid
Solvent B:100% acetonitrile; 0.2% formic acid for RP; 100% methanol with Biocrates FIa Solvent
Chromatography Type:Reversed phase