Summary of Study ST000978

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000668. The data can be accessed directly via it's Project DOI: 10.21228/M8B69G This work is supported by NIH grant, U2C- DK119886.

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Study IDST000978
Study TitleMetabolomics biomarkers and the risk of overall mortality and ESRD in CKD: results from the Progredir Cohort.
Study Typeongoing cohort study
Study Summary454 CKD participants were originally recruited from the outpatient services from Hospital das Clinicas, Sao Paulo. Extensive baseline data and biobank were collected between 2012-2013 in the Clinical Research Center, Universitary Hospital, Sao Paulo. Participants are being actively followed for events of mortality, renal replacement therapy and CVD. Death certificates are obtained from State and National Registries. For the this uploaded data, events were determined up to May 2017 (median follow-up time of 3 y). Censoring data was considered as the last day of contact.
Institute
University of Sao Paulo
DepartmentClinical Research Center, Universitary Hospital, Sao Paulo University
LaboratoryLaboratory of Genetics and Molecular Cardiology, Heart Institute
Last NameTitan
First NameSilvia
Address255 Av Dr Eneas Carvalho Aguiar, Cerqueira César, Sao Paulo, Sp, Brazil, 05403-000
Emailsmotitan@gmail.com
Phone+1-413-362-4377
Submit Date2018-05-22
Total Subjects451
Study CommentsEvents are overall mortality, RRT, and a composite outcome of mortality and RRT. In addition, we also provided the variable for competitive data analysis (RRT considering the competing effect of death). Please see below for description of Study Design. Cox_mortality: death events (for Cox proportional hazard models) Cox_RRT: renal replacement therapy events (for Cox proportional hazard models) Cox_composite_deathRRT: death events AND renal replacement therapy events (for Cox proportional hazard models) Competitive_RRTvs death: death or renal replacement therapy events (for competitive risk analysis) Time_death: follow-up time for death events and censored-participants (for Cox models) Time_Cox_RRT: follow-up time for renal replacement therapy events and censored-participants (for Cox models) Time_composite_deathRRT: follow-up time for death AND renal replacement therapy and censored-participants (for Cox models) Time_competitive_TRSvsDeath: follow-up time for renal replacement therapy, death or censored-participants (for competitive analysis)
Analysis Type DetailGC-MS
Release Date2018-07-17
Release Version1
Silvia Titan Silvia Titan
https://dx.doi.org/10.21228/M8B69G
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN001602
Analysis type MS
Chromatography type GC
Chromatography system Agilent 7890B
Column DB5-MS + 10m Duraguard capillary column (Agilent 122-5532G)
MS Type EI
MS instrument type Single quadrupole
MS instrument name Agilent 5975C
Ion Mode POSITIVE
Units peak height

Chromatography:

Chromatography ID:CH001124
Instrument Name:Agilent 7890B
Column Name:DB5-MS + 10m Duraguard capillary column (Agilent 122-5532G)
Column Temperature:60°C for 1 min, and then increased to 310°C at a rate of 10°C/min
Flow Rate:0.736ml/min
Injection Temperature:250C
Sample Injection:1uL
Analytical Time:37 minutes
Capillary Voltage:70eV
Oven Temperature:60°C for 1 min, and then increased to 310°C at a rate of 10°C/min
Weak Wash Solvent Name:Methanol
Weak Wash Volume:3x 5uL
Strong Wash Solvent Name:Isopropanol
Strong Wash Volume:3x 5uL
Sample Syringe Size:10uL
Chromatography Type:GC
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