Summary of Study ST001434
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000985. The data can be accessed directly via it's Project DOI: 10.21228/M8CH6R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001434 |
| Study Title | Untargeted lipidomics of liver to assess the potential protective role in atherosclerosis progression of A12 antibodies infusion into LDLR-/-mice |
| Study Type | LC-MS Untargeted Lipidomics |
| Study Summary | In order to assess the therapeutic potential of A12 antibodies in atherosclerosis, untargeted lipidomics of liver samples was performed. LDLR-/-mice were treated with a fully murine version of the A12 antibody (mA12-IgG2b), with the isotype control antibody mB1.8-IgG2b (n=16) or with PBS as controls. |
| Institute | Centro Nacional de Investigaciones Cardiovasculares Carlos III |
| Last Name | Ferrarini |
| First Name | Alessia |
| Address | Calle de Melchor Fernández Almagro, 3, 28029 Madrid |
| aferrarini@cnic.es | |
| Phone | +34 914 53 12 00 |
| Submit Date | 2020-07-27 |
| Num Groups | 3 |
| Total Subjects | 18 |
| Publications | DOI. 10.1038/s41586-020-2993-2 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2020-09-25 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN002396 | AN002397 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | Reversed phase | Reversed phase |
| Chromatography system | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 |
| Column | Agilent mRP-Recovery C18 column (100 x 0.5mm,5um) | Agilent mRP-Recovery C18 column (100 x 0.5mm,5um) |
| MS Type | ESI | ESI |
| MS instrument type | Orbitrap | Orbitrap |
| MS instrument name | Thermo Orbitrap Elite Hybrid Ion Trap-Orbitrap | Thermo Orbitrap Elite Hybrid Ion Trap-Orbitrap |
| Ion Mode | POSITIVE | NEGATIVE |
| Units | peak area | peak area |
Chromatography:
| Chromatography ID: | CH001761 |
| Instrument Name: | Thermo Dionex Ultimate 3000 |
| Column Name: | Agilent mRP-Recovery C18 column (100 x 0.5mm,5um) |
| Chromatography Type: | Reversed phase |
