Summary of study ST001428

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000980. The data can be accessed directly via it's Project DOI: 10.21228/M8169P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001428
Study TitleRole of environmental toxicants in modulating disease severity in children with NAFLD
Study SummaryThis project aims to further understand about how the environment impacts nonalcoholic fatty liver disease NAFLD and nonalcoholic steatohepatitis (NASH) in children. At present the NASH CRN has the largest, well characterized cohort of children with NAFLD, including clinical data, labs, cytokines, genetic polymorphisms, but no proteomics, metabolomics, lipidomics or toxicant assessment. Exposure and untargeted metabolomics analyses will examine the role of environmental toxicants in modulating disease severity and the endogenous response to exposures in children with NAFLD.
Institute
Emory University
DepartmentSchool of Medicine
LaboratoryClincal Biomarkers Laboratory
Last NameTran
First NameViLinh
Address615 Michael St, suite 225, Atlanta GA 30322
Emailvtran6@emory.edu
Phone9122281788
Submit Date2020-07-17
Total Subjects427
Study CommentsBoth CHEAR pooled plasma samples and Clinical Biomarker Laboratory pooled plasma samples were used
Raw Data AvailableYes
Raw Data File Type(s).raw
Chear Study2017-1593
Analysis Type DetailLC-MS
Release Date2020-07-30
Release Version1
ViLinh Tran ViLinh Tran
https://dx.doi.org/10.21228/M8169P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO001497
Collection Summary:Serum obtained from blood vein draw for children, which are acquired near in time to liver biopsy, for the subject in the NASH CRN cohort. Blood samples were collected in red top vacutainer tubers and sit upright for 30 minutes for clot formation, followed by centrifugation and removal of 500uL aliquots of serum to 1.8mL freezer tubes and stores in a -70C freezer. The samples were shipped on dry ice from the clinical centers to CHEAR URR at Emory University.
Sample Type:Blood (serum)
Storage Conditions:Described in summary
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