Summary of Study ST001929
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001218. The data can be accessed directly via it's Project DOI: 10.21228/M88H76 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001929 |
Study Title | Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype (Part 2) |
Study Summary | Urinary O-desmethylangolensin (ODMA) concentrations provide a functional gut microbiome marker of dietary isoflavone daidzein metabolism to ODMA. Individuals who do not have gut microbial environments that produce ODMA have less favorable cardiometabolic and cancer risk profiles. Urinary metabolomics profiles were evaluated in relation to ODMA metabotypes within and between individuals over time. Secondary analysis was conducted of data from the BEAN2 trial, which was a cross-over study of premenopausal women consuming six months on a high- and a low-soy diet, each separated by a 1-month washout period. In all of the 672 samples in the study, 66 of the 84 women had the same ODMA metabotype at seven or all eight time points. Two or four urine samples per woman were selected based on temporal metabotypes in order to compare within and across individuals. Metabolomics assays for primary metabolism and biogenic amines were conducted in 60 urine samples from 20 women. |
Institute | George Mason University |
Last Name | Frankenfeld |
First Name | Cara |
Address | 4400 University Drive, Fairfax, VA 22030 |
prof.frankenfeld@gmail.com | |
Phone | 2062652563 |
Submit Date | 2021-08-23 |
Raw Data Available | Yes |
Analysis Type Detail | GC-MS |
Release Date | 2021-11-02 |
Release Version | 1 |
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Collection:
Collection ID: | CO002000 |
Collection Summary: | Urine biospecimens were collected during cross-over trial among premenopausal women conducted from 2007-2010, and details about the study design and population are published elsewhere (Morimoto et al 2014; Maskarinec et al 2011; Maskarinec et al 2012). The BEAN2 trial was a cross-over study with six months on a high- and a low-soy diet, each separated by a 1-month washout period. The objective of the study was to evaluate soy intake and nipple aspirate fluid, a possible indicator of breast cancer risk. Eligibility criteria for the parent study included a normal mammogram, no oral contraceptives, not pregnant, no previous cancer diagnosis or breast surgery, regular menstrual periods, low soy intake, and the ability to produce nipple aspirate fluid. There were 84 women from the original trial who had eight stored urine samples over the cross-over intervention, from which 60 samples were selected for metabolomics analysis. |
Sample Type: | Urine |