Summary of Study ST000441
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000340. The data can be accessed directly via it's Project DOI: 10.21228/M85G6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000441 |
Study Title | Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways |
Study Summary | Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 of the drug-like compounds from the Malaria Box) using ultra-high performance liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic fingerprints provide information on the parasite biochemical pathways affected by pharmacologic intervention and offer a critical blueprint for selecting and advancing lead compounds as next-generation antimalarial drugs. Our results reveal several major classes of metabolic disruption, which allow us to predict the mode-of-action (MoA) for many of the Malaria Box compounds. |
Institute | Pennsylvania State University |
Last Name | Llinás |
First Name | Manuel |
Address | W126 Millenium Science Complex, University Park, PA 16802 |
manuel@psu.edu | |
Phone | (814) 867-3527 |
Submit Date | 2016-07-11 |
Publications | doi: 10.1128/AAC.01224-16 |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2016-12-22 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: MACS purified infected RBCs; Subject species: Plasmodium falciparum (Factor headings shown in green)
mb_sample_id | local_sample_id | Drug |
---|---|---|
SA022350 | Atovaquone | Atovaquone |
SA022349 | AZ412 | AZ412 |
SA022351 | Chloroquine | Chloroquine |
SA022352 | DDD498 | DDD498 |
SA022355 | Deoxyglucose | Deoxyglucose |
SA022353 | DSM1 | DSM1 |
SA022354 | DSM265 | DSM265 |
SA022356 | ELQ-300 | ELQ-300 |
SA022357 | KAF156_analogue | KAF156_analogue |
SA022358 | KAF246 | KAF246 |
SA022359 | MMV000248 | MMV000248 |
SA022360 | MMV000356 | MMV000356 |
SA022361 | MMV000483 | MMV000483 |
SA022362 | MMV000498 | MMV000498 |
SA022363 | MMV000561 | MMV000561 |
SA022364 | MMV000563 | MMV000563 |
SA022365 | MMV000620 | MMV000620 |
SA022366 | MMV000634 | MMV000634 |
SA022367 | MMV000653 | MMV000653 |
SA022368 | MMV000662 | MMV000662 |
SA022369 | MMV000760 | MMV000760 |
SA022370 | MMV000788 | MMV000788 |
SA022371 | MMV000848 | MMV000848 |
SA022372 | MMV000963 | MMV000963 |
SA022373 | MMV000972 | MMV000972 |
SA022374 | MMV001038 | MMV001038 |
SA022375 | MMV001049 | MMV001049 |
SA022376 | MMV001230 | MMV001230 |
SA022377 | MMV001246 | MMV001246 |
SA022378 | MMV001255 | MMV001255 |
SA022379 | MMV001344 | MMV001344 |
SA022380 | MMV006087 | MMV006087 |
SA022381 | MMV006188 | MMV006188 |
SA022382 | MMV006278 | MMV006278 |
SA022383 | MMV006319 | MMV006319 |
SA022384 | MMV006427 | MMV006427 |
SA022385 | MMV006429 | MMV006429 |
SA022386 | MMV006455 | MMV006455 |
SA022387 | MMV006545 | MMV006545 |
SA022388 | MMV006587 | MMV006587 |
SA022389 | MMV006704 | MMV006704 |
SA022390 | MMV006706 | MMV006706 |
SA022391 | MMV006767 | MMV006767 |
SA022392 | MMV006820 | MMV006820 |
SA022393 | MMV006913 | MMV006913 |
SA022394 | MMV006937 | MMV006937 |
SA022395 | MMV007116 | MMV007116 |
SA022396 | MMV007430 | MMV007430 |
SA022397 | MMV007564 | MMV007564 |
SA022398 | MMV007571 | MMV007571 |
SA022399 | MMV007617 | MMV007617 |
SA022400 | MMV007808 | MMV007808 |
SA022401 | MMV007839 | MMV007839 |
SA022402 | MMV007875 | MMV007875 |
SA022403 | MMV007881 | MMV007881 |
SA022404 | MMV007906 | MMV007906 |
SA022405 | MMV007907 | MMV007907 |
SA022406 | MMV007977 | MMV007977 |
SA022407 | MMV007978 | MMV007978 |
SA022408 | MMV008127 | MMV008127 |
SA022409 | MMV008138 | MMV008138 |
SA022410 | MMV008149 | MMV008149 |
SA022411 | MMV008212 | MMV008212 |
SA022412 | MMV008270 | MMV008270 |
SA022413 | MMV008956 | MMV008956 |
SA022414 | MMV009063 | MMV009063 |
SA022415 | MMV009108 | MMV009108 |
SA022416 | MMV011099 | MMV011099 |
SA022417 | MMV011256 | MMV011256 |
SA022418 | MMV011259 | MMV011259 |
SA022419 | MMV011567 | MMV011567 |
SA022420 | MMV011576 | MMV011576 |
SA022421 | MMV011795 | MMV011795 |
SA022422 | MMV011944 | MMV011944 |
SA022423 | MMV018984 | MMV018984 |
SA022424 | MMV019017 | MMV019017 |
SA022425 | MMV019064 | MMV019064 |
SA022426 | MMV019066 | MMV019066 |
SA022427 | MMV019074 | MMV019074 |
SA022428 | MMV019110 | MMV019110 |
SA022429 | MMV019124 | MMV019124 |
SA022430 | MMV019127 | MMV019127 |
SA022431 | MMV019202 | MMV019202 |
SA022432 | MMV019258 | MMV019258 |
SA022433 | MMV019266 | MMV019266 |
SA022434 | MMV019313 | MMV019313 |
SA022435 | MMV019662 | MMV019662 |
SA022436 | MMV019670 | MMV019670 |
SA022437 | MMV019700 | MMV019700 |
SA022438 | MMV019738 | MMV019738 |
SA022439 | MMV019758 | MMV019758 |
SA022440 | MMV019780 | MMV019780 |
SA022441 | MMV019871 | MMV019871 |
SA022442 | MMV020275 | MMV020275 |
SA022443 | MMV020439 | MMV020439 |
SA022444 | MMV020490 | MMV020490 |
SA022445 | MMV020492 | MMV020492 |
SA022446 | MMV020500 | MMV020500 |
SA022447 | MMV020505 | MMV020505 |
SA022448 | MMV020548 | MMV020548 |