Summary of Study ST000645

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000460. The data can be accessed directly via it's Project DOI: 10.21228/M8M027 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000645
Study TitleEffects of Exercise on Dystrophic Mouse Muscle Amino Acids (part I)
Study SummaryWe will use male C57BL10, mdx, and nNOS-/- mice (n = 10 each group) to characterize the skeletal and cardiac muscle metabolomes. Half of the mice in each group will remain sedentary while the other half will be subjected to a single bout of treadmill exercise to exhaustion. Mice will be euthanized immediately postexercise and blood, hearts, and hindlimb muscles will be harvested and frozen as detailed in the General Methods. The heart and gastrocnemius, soleus, and quadriceps muscles of one hindlimb will be sent to the Mayo Clinic Metabolomics Resource Core. The heart and quadriceps muscle will be used for untargeted metabolomics profiling (LC/MS) while the gastrocnemius and soleus muscles will be used for targeted analyses of amino acids plus amino metabolites, non-esterified fatty acids, and citric acid cycle intermediates.
Institute
Mayo Clinic
Last NameThomas
First NameGail
AddressPenn State Hershey Heart and Vascular Institute Penn State College of Medicine 500 University Drive, MC H047 Hershey, PA 17033
Emailgthomas4@hmc.psu.edu
Phone717-531-0003, ext. 287087
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Gail Thomas Gail Thomas
https://dx.doi.org/10.21228/M8M027
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Time point Grouping
SA036439ms5942-7Post Run RUN-BL10 Control
SA036440ms5942-9Post Run RUN-BL10 Control
SA036441ms5942-10Post Run RUN-BL10 Control
SA036442ms5942-6Post Run RUN-BL10 Control
SA036443ms5942-8Post Run RUN-BL10 Control
SA036444ms5942-28Post Run RUN-MDX
SA036445ms5942-26Post Run RUN-MDX
SA036446ms5942-30Post Run RUN-MDX
SA036447ms5942-27Post Run RUN-MDX
SA036448ms5942-29Post Run RUN-MDX
SA036449ms5942-18Post Run RUN-nNOS-/-
SA036450ms5942-19Post Run RUN-nNOS-/-
SA036451ms5942-20Post Run RUN-nNOS-/-
SA036452ms5942-17Post Run RUN-nNOS-/-
SA036453ms5942-16Post Run RUN-nNOS-/-
SA036454ms5942-5Sedentary SED-BL10 Control
SA036455ms5942-4Sedentary SED-BL10 Control
SA036456ms5942-3Sedentary SED-BL10 Control
SA036457ms5942-1Sedentary SED-BL10 Control
SA036458ms5942-2Sedentary SED-BL10 Control
SA036459ms5942-25Sedentary SED-MDX
SA036460ms5942-24Sedentary SED-MDX
SA036461ms5942-21Sedentary SED-MDX
SA036462ms5942-22Sedentary SED-MDX
SA036463ms5942-23Sedentary SED-MDX
SA036464ms5942-15Sedentary SED-nNOS-/-
SA036465ms5942-14Sedentary SED-nNOS-/-
SA036466ms5942-11Sedentary SED-nNOS-/-
SA036467ms5942-12Sedentary SED-nNOS-/-
SA036468ms5942-13Sedentary SED-nNOS-/-
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