Summary of Study ST001348
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000917. The data can be accessed directly via it's Project DOI: 10.21228/M8568J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001348 |
| Study Title | Metabolomic changes in mouse liver on a threonine restricted diet (part-III) |
| Study Summary | The data provided here are in support of the publication “Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution” Yann W. Yap et al. Nature Communications 2020 (accepted for publication). The data in this study corresponds to liver from C57Bl/6JMarp mice subject to a 3wk treatment with diets either containing 18% digestible energy from amino acids with either a normal distribution of amino acids or with restricted amounts of threonine. This followed prior treatment with adeno-associated viruses to transduce the liver to express yeast threonine biosynthetic enzymes (AAV-yTHR1+THR4) or a negative control (AAV-GFP). n= 6 individual mice per group. |
| Institute | Monash University |
| Department | Department of Biochemistry and Molecular Biology |
| Laboratory | Nutrient Metabolism and Signalling Laboratory |
| Last Name | Rose |
| First Name | Adam |
| Address | Monash University, Clayton Campus, 23 Innovation Walk, Clayton, Victoria, 3800, Australia |
| adam.rose@monash.edu | |
| Phone | +61 3 99029340 |
| Submit Date | 2020-04-03 |
| Num Groups | 4 |
| Total Subjects | 24 |
| Num Males | 24 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2020-07-20 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Diet | Virus treatment |
|---|---|---|---|
| SA097876 | AR401_control_AA_GFP_1pt1 | Control diet SF17-177 | AAV-GFP |
| SA097877 | AR406_control_AA_GFP_2pt3 | Control diet SF17-177 | AAV-GFP |
| SA097878 | AR405_control_AA_GFP_2pt2 | Control diet SF17-177 | AAV-GFP |
| SA097879 | AR402_control_AA_GFP_1pt2 | Control diet SF17-177 | AAV-GFP |
| SA097880 | AR403_control_AA_GFP_1pt3 | Control diet SF17-177 | AAV-GFP |
| SA097881 | AR404_control_AA_GFP_2pt1 | Control diet SF17-177 | AAV-GFP |
| SA097882 | AR412_control_AA_THR1plus4_4pt3 | Control diet SF17-177 | AAV-yTHR1+THR4 |
| SA097883 | AR411_control_AA_THR1plus4_4pt2 | Control diet SF17-177 | AAV-yTHR1+THR4 |
| SA097884 | AR408_control_AA_THR1plus4_3pt2 | Control diet SF17-177 | AAV-yTHR1+THR4 |
| SA097885 | AR407_control_AA_THR1plus4_3pt1 | Control diet SF17-177 | AAV-yTHR1+THR4 |
| SA097886 | AR410_control_AA_THR1plus4_4pt1 | Control diet SF17-177 | AAV-yTHR1+THR4 |
| SA097887 | AR409_control_AA_THR1plus4_3pt3 | Control diet SF17-177 | AAV-yTHR1+THR4 |
| SA097888 | AR418_Low_T_GFP_6pt3 | Low Threonine diet SF18-066 | AAV-GFP |
| SA097889 | AR417_Low_T_GFP_6pt2 | Low Threonine diet SF18-066 | AAV-GFP |
| SA097890 | AR413_Low_T_GFP_5pt1 | Low Threonine diet SF18-066 | AAV-GFP |
| SA097891 | AR416_Low_T_GFP_6pt1 | Low Threonine diet SF18-066 | AAV-GFP |
| SA097892 | AR414_Low_T_GFP_5pt2 | Low Threonine diet SF18-066 | AAV-GFP |
| SA097893 | AR415_Low_T_GFP_5pt3 | Low Threonine diet SF18-066 | AAV-GFP |
| SA097894 | AR424_Low_T_THR1plus4_8pt3 | Low Threonine diet SF18-066 | AAV-yTHR1+THR4 |
| SA097895 | AR423_Low_T_THR1plus4_8pt2 | Low Threonine diet SF18-066 | AAV-yTHR1+THR4 |
| SA097896 | AR421_Low_T_THR1plus4_7pt3 | Low Threonine diet SF18-066 | AAV-yTHR1+THR4 |
| SA097897 | AR419_Low_T_THR1plus4_7pt1 | Low Threonine diet SF18-066 | AAV-yTHR1+THR4 |
| SA097898 | AR420_Low_T_THR1plus4_7pt2 | Low Threonine diet SF18-066 | AAV-yTHR1+THR4 |
| SA097899 | AR422_Low_T_THR1plus4_8pt1 | Low Threonine diet SF18-066 | AAV-yTHR1+THR4 |
| Showing results 1 to 24 of 24 |
