Summary of Study ST001637

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001047. The data can be accessed directly via it's Project DOI: 10.21228/M8C68D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST001637
Study Title	A Metabolome Atlas of the Aging Mouse Brain
Study Summary	The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remains poorly understood. To start bridging this gap, we generated a metabolome atlas of the aging mouse brain from 10 anatomical regions spanning from adolescence to late adulthood. We combined data from three chromatography-based mass spectrometry assays and structurally annotated 1,709 metabolites to reveal the underlying architecture of aging-induced changes in the brain metabolome. Overall differences between sexes were minimal. We found 94% of all metabolites to significantly differ between brain sections in at least one age group. We also discovered that 90% of the metabolome showed significant changes with respect to age groups. For example, we identified a shift in sphingolipid patterns during aging that is related to myelin remodeling in the transition from adolescent to adult brains. This shift was accompanied by large changes in overall signature in a range of other metabolic pathways. We found clear metabolic similarities in brain sections that were functionally related such as brain stem, cerebrum and cerebellum. In cerebrum, metabolic correlation patterns got markedly weaker in the transition from adolescent to ear adults, whereas correlation patterns between cerebrum and brainstem regions decreased from early to late adulthood. We were also able to map metabolic changes to gene and protein brain atlases to link molecular changes to metabolic brain phenotypes. Metabolic profiles can be investigated via https://atlas.metabolomics.us/. This new resource enables brain researchers to link new metabolomic studies to a foundation data set.
Institute	University of California, Davis
Department	Genome Center
Laboratory	West Coast Metabolomics Center
Last Name	Ding
First Name	Jun
Address	451 East Health Science Drive, Davis, CA, 95616, USA
Email	junding@ucdavis.edu
Phone	773-326-5420
Submit Date	2020-12-23
Raw Data Available	Yes
Raw Data File Type(s)	raw(Thermo)
Analysis Type Detail	GC-MS/LC-MS
Release Date	2021-08-30
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id	local_sample_id	Brain region	Age	Gender
SA149974	EA_F4_BG	Basal ganglia	16 weeks	Female
SA149975	EA_F3_BG	Basal ganglia	16 weeks	Female
SA149976	EA_F5_BG	Basal ganglia	16 weeks	Female
SA149977	EA_F7_BG	Basal ganglia	16 weeks	Female
SA149978	EA_F8_BG	Basal ganglia	16 weeks	Female
SA149979	EA_F1_BG	Basal ganglia	16 weeks	Female
SA149980	EA_F6_BG	Basal ganglia	16 weeks	Female
SA149981	EA_F2_BG	Basal ganglia	16 weeks	Female
SA149982	EA_M4_BG	Basal ganglia	16 weeks	Male
SA149983	EA_M3_BG	Basal ganglia	16 weeks	Male
SA149984	EA_M2_BG	Basal ganglia	16 weeks	Male
SA149985	EA_M1_BG	Basal ganglia	16 weeks	Male
SA149986	EA_M5_BG	Basal ganglia	16 weeks	Male
SA149987	EA_M6_BG	Basal ganglia	16 weeks	Male
SA149988	EA_M7_BG	Basal ganglia	16 weeks	Male
SA149989	EA_M8_BG	Basal ganglia	16 weeks	Male
SA149990	AD_F3_BG	Basal ganglia	3 weeks	Female
SA149991	AD_F2_BG	Basal ganglia	3 weeks	Female
SA149992	AD_F1_BG	Basal ganglia	3 weeks	Female
SA149993	AD_F5_BG	Basal ganglia	3 weeks	Female
SA149994	AD_F4_BG	Basal ganglia	3 weeks	Female
SA149995	AD_F7_BG	Basal ganglia	3 weeks	Female
SA149996	AD_F8_BG	Basal ganglia	3 weeks	Female
SA149997	AD_F6_BG	Basal ganglia	3 weeks	Female
SA149998	AD_M5_BG	Basal ganglia	3 weeks	Male
SA149999	AD_M4_BG	Basal ganglia	3 weeks	Male
SA150000	AD_M3_BG	Basal ganglia	3 weeks	Male
SA150001	AD_M6_BG	Basal ganglia	3 weeks	Male
SA150002	AD_M8_BG	Basal ganglia	3 weeks	Male
SA150003	AD_M7_BG	Basal ganglia	3 weeks	Male
SA150004	AD_M1_BG	Basal ganglia	3 weeks	Male
SA150005	AD_M2_BG	Basal ganglia	3 weeks	Male
SA150006	LA_F7_BG	Basal ganglia	59 weeks	Female
SA150007	LA_F6_BG	Basal ganglia	59 weeks	Female
SA150008	LA_F8_BG	Basal ganglia	59 weeks	Female
SA150009	LA_F1_BG	Basal ganglia	59 weeks	Female
SA150010	LA_F2_BG	Basal ganglia	59 weeks	Female
SA150011	LA_F3_BG	Basal ganglia	59 weeks	Female
SA150012	LA_F5_BG	Basal ganglia	59 weeks	Female
SA150013	LA_F4_BG	Basal ganglia	59 weeks	Female
SA150014	LA_M6_BG	Basal ganglia	59 weeks	Male
SA150015	LA_M8_BG	Basal ganglia	59 weeks	Male
SA150016	LA_M5_BG	Basal ganglia	59 weeks	Male
SA150017	LA_M7_BG	Basal ganglia	59 weeks	Male
SA150018	LA_M4_BG	Basal ganglia	59 weeks	Male
SA150019	LA_M2_BG	Basal ganglia	59 weeks	Male
SA150020	LA_M1_BG	Basal ganglia	59 weeks	Male
SA150021	LA_M3_BG	Basal ganglia	59 weeks	Male
SA150022	EA_F5_CB	Cerebellum	16 weeks	Female
SA150023	EA_F6_CB	Cerebellum	16 weeks	Female
SA150024	EA_F7_CB	Cerebellum	16 weeks	Female
SA150025	EA_F4_CB	Cerebellum	16 weeks	Female
SA150026	EA_F3_CB	Cerebellum	16 weeks	Female
SA150027	EA_F2_CB	Cerebellum	16 weeks	Female
SA150028	EA_F8_CB	Cerebellum	16 weeks	Female
SA150029	EA_F1_CB	Cerebellum	16 weeks	Female
SA150030	EA_M8_CB	Cerebellum	16 weeks	Male
SA150031	EA_M6_CB	Cerebellum	16 weeks	Male
SA150032	EA_M7_CB	Cerebellum	16 weeks	Male
SA150033	EA_M5_CB	Cerebellum	16 weeks	Male
SA150034	EA_M4_CB	Cerebellum	16 weeks	Male
SA150035	EA_M2_CB	Cerebellum	16 weeks	Male
SA150036	EA_M3_CB	Cerebellum	16 weeks	Male
SA150037	EA_M1_CB	Cerebellum	16 weeks	Male
SA150038	AD_F8_CB	Cerebellum	3 weeks	Female
SA150039	AD_F6_CB	Cerebellum	3 weeks	Female
SA150040	AD_F7_CB	Cerebellum	3 weeks	Female
SA150041	AD_F5_CB	Cerebellum	3 weeks	Female
SA150042	AD_F3_CB	Cerebellum	3 weeks	Female
SA150043	AD_F2_CB	Cerebellum	3 weeks	Female
SA150044	AD_F1_CB	Cerebellum	3 weeks	Female
SA150045	AD_F4_CB	Cerebellum	3 weeks	Female
SA150046	AD_M6_CB	Cerebellum	3 weeks	Male
SA150047	AD_M8_CB	Cerebellum	3 weeks	Male
SA150048	AD_M1_CB	Cerebellum	3 weeks	Male
SA150049	AD_M5_CB	Cerebellum	3 weeks	Male
SA150050	AD_M7_CB	Cerebellum	3 weeks	Male
SA150051	AD_M2_CB	Cerebellum	3 weeks	Male
SA150052	AD_M3_CB	Cerebellum	3 weeks	Male
SA150053	AD_M4_CB	Cerebellum	3 weeks	Male
SA150054	LA_F7_CB	Cerebellum	59 weeks	Female
SA150055	LA_F8_CB	Cerebellum	59 weeks	Female
SA150056	LA_F6_CB	Cerebellum	59 weeks	Female
SA150057	LA_F3_CB	Cerebellum	59 weeks	Female
SA150058	LA_F5_CB	Cerebellum	59 weeks	Female
SA150059	LA_F2_CB	Cerebellum	59 weeks	Female
SA150060	LA_F1_CB	Cerebellum	59 weeks	Female
SA150061	LA_F4_CB	Cerebellum	59 weeks	Female
SA150062	LA_M7_CB	Cerebellum	59 weeks	Male
SA150063	LA_M6_CB	Cerebellum	59 weeks	Male
SA150064	LA_M8_CB	Cerebellum	59 weeks	Male
SA150065	LA_M1_CB	Cerebellum	59 weeks	Male
SA150066	LA_M5_CB	Cerebellum	59 weeks	Male
SA150067	LA_M3_CB	Cerebellum	59 weeks	Male
SA150068	LA_M2_CB	Cerebellum	59 weeks	Male
SA150069	LA_M4_CB	Cerebellum	59 weeks	Male
SA150070	EA_F6_CT	Cerebral cortex	16 weeks	Female
SA150071	EA_F7_CT	Cerebral cortex	16 weeks	Female
SA150072	EA_F5_CT	Cerebral cortex	16 weeks	Female
SA150073	EA_F2_CT	Cerebral cortex	16 weeks	Female