Summary of Study ST001637

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001047. The data can be accessed directly via it's Project DOI: 10.21228/M8C68D This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001637
Study TitleA Metabolome Atlas of the Aging Mouse Brain
Study SummaryThe mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remains poorly understood. To start bridging this gap, we generated a metabolome atlas of the aging mouse brain from 10 anatomical regions spanning from adolescence to late adulthood. We combined data from three chromatography-based mass spectrometry assays and structurally annotated 1,709 metabolites to reveal the underlying architecture of aging-induced changes in the brain metabolome. Overall differences between sexes were minimal. We found 94% of all metabolites to significantly differ between brain sections in at least one age group. We also discovered that 90% of the metabolome showed significant changes with respect to age groups. For example, we identified a shift in sphingolipid patterns during aging that is related to myelin remodeling in the transition from adolescent to adult brains. This shift was accompanied by large changes in overall signature in a range of other metabolic pathways. We found clear metabolic similarities in brain sections that were functionally related such as brain stem, cerebrum and cerebellum. In cerebrum, metabolic correlation patterns got markedly weaker in the transition from adolescent to ear adults, whereas correlation patterns between cerebrum and brainstem regions decreased from early to late adulthood. We were also able to map metabolic changes to gene and protein brain atlases to link molecular changes to metabolic brain phenotypes. Metabolic profiles can be investigated via This new resource enables brain researchers to link new metabolomic studies to a foundation data set.
University of California, Davis
DepartmentGenome Center
LaboratoryWest Coast Metabolomics Center
Last NameDing
First NameJun
Address451 East Health Science Drive, Davis, CA, 95616, USA
Submit Date2020-12-23
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailGC-MS/LC-MS
Release Date2021-08-30
Release Version1
Jun Ding Jun Ding application/zip

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Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Brain region Age Gender
SA149974EA_F4_BGBasal ganglia 16 weeks Female
SA149975EA_F3_BGBasal ganglia 16 weeks Female
SA149976EA_F5_BGBasal ganglia 16 weeks Female
SA149977EA_F7_BGBasal ganglia 16 weeks Female
SA149978EA_F8_BGBasal ganglia 16 weeks Female
SA149979EA_F1_BGBasal ganglia 16 weeks Female
SA149980EA_F6_BGBasal ganglia 16 weeks Female
SA149981EA_F2_BGBasal ganglia 16 weeks Female
SA149982EA_M4_BGBasal ganglia 16 weeks Male
SA149983EA_M3_BGBasal ganglia 16 weeks Male
SA149984EA_M2_BGBasal ganglia 16 weeks Male
SA149985EA_M1_BGBasal ganglia 16 weeks Male
SA149986EA_M5_BGBasal ganglia 16 weeks Male
SA149987EA_M6_BGBasal ganglia 16 weeks Male
SA149988EA_M7_BGBasal ganglia 16 weeks Male
SA149989EA_M8_BGBasal ganglia 16 weeks Male
SA149990AD_F3_BGBasal ganglia 3 weeks Female
SA149991AD_F2_BGBasal ganglia 3 weeks Female
SA149992AD_F1_BGBasal ganglia 3 weeks Female
SA149993AD_F5_BGBasal ganglia 3 weeks Female
SA149994AD_F4_BGBasal ganglia 3 weeks Female
SA149995AD_F7_BGBasal ganglia 3 weeks Female
SA149996AD_F8_BGBasal ganglia 3 weeks Female
SA149997AD_F6_BGBasal ganglia 3 weeks Female
SA149998AD_M5_BGBasal ganglia 3 weeks Male
SA149999AD_M4_BGBasal ganglia 3 weeks Male
SA150000AD_M3_BGBasal ganglia 3 weeks Male
SA150001AD_M6_BGBasal ganglia 3 weeks Male
SA150002AD_M8_BGBasal ganglia 3 weeks Male
SA150003AD_M7_BGBasal ganglia 3 weeks Male
SA150004AD_M1_BGBasal ganglia 3 weeks Male
SA150005AD_M2_BGBasal ganglia 3 weeks Male
SA150006LA_F7_BGBasal ganglia 59 weeks Female
SA150007LA_F6_BGBasal ganglia 59 weeks Female
SA150008LA_F8_BGBasal ganglia 59 weeks Female
SA150009LA_F1_BGBasal ganglia 59 weeks Female
SA150010LA_F2_BGBasal ganglia 59 weeks Female
SA150011LA_F3_BGBasal ganglia 59 weeks Female
SA150012LA_F5_BGBasal ganglia 59 weeks Female
SA150013LA_F4_BGBasal ganglia 59 weeks Female
SA150014LA_M6_BGBasal ganglia 59 weeks Male
SA150015LA_M8_BGBasal ganglia 59 weeks Male
SA150016LA_M5_BGBasal ganglia 59 weeks Male
SA150017LA_M7_BGBasal ganglia 59 weeks Male
SA150018LA_M4_BGBasal ganglia 59 weeks Male
SA150019LA_M2_BGBasal ganglia 59 weeks Male
SA150020LA_M1_BGBasal ganglia 59 weeks Male
SA150021LA_M3_BGBasal ganglia 59 weeks Male
SA150022EA_F5_CBCerebellum 16 weeks Female
SA150023EA_F6_CBCerebellum 16 weeks Female
SA150024EA_F7_CBCerebellum 16 weeks Female
SA150025EA_F4_CBCerebellum 16 weeks Female
SA150026EA_F3_CBCerebellum 16 weeks Female
SA150027EA_F2_CBCerebellum 16 weeks Female
SA150028EA_F8_CBCerebellum 16 weeks Female
SA150029EA_F1_CBCerebellum 16 weeks Female
SA150030EA_M8_CBCerebellum 16 weeks Male
SA150031EA_M6_CBCerebellum 16 weeks Male
SA150032EA_M7_CBCerebellum 16 weeks Male
SA150033EA_M5_CBCerebellum 16 weeks Male
SA150034EA_M4_CBCerebellum 16 weeks Male
SA150035EA_M2_CBCerebellum 16 weeks Male
SA150036EA_M3_CBCerebellum 16 weeks Male
SA150037EA_M1_CBCerebellum 16 weeks Male
SA150038AD_F8_CBCerebellum 3 weeks Female
SA150039AD_F6_CBCerebellum 3 weeks Female
SA150040AD_F7_CBCerebellum 3 weeks Female
SA150041AD_F5_CBCerebellum 3 weeks Female
SA150042AD_F3_CBCerebellum 3 weeks Female
SA150043AD_F2_CBCerebellum 3 weeks Female
SA150044AD_F1_CBCerebellum 3 weeks Female
SA150045AD_F4_CBCerebellum 3 weeks Female
SA150046AD_M6_CBCerebellum 3 weeks Male
SA150047AD_M8_CBCerebellum 3 weeks Male
SA150048AD_M1_CBCerebellum 3 weeks Male
SA150049AD_M5_CBCerebellum 3 weeks Male
SA150050AD_M7_CBCerebellum 3 weeks Male
SA150051AD_M2_CBCerebellum 3 weeks Male
SA150052AD_M3_CBCerebellum 3 weeks Male
SA150053AD_M4_CBCerebellum 3 weeks Male
SA150054LA_F7_CBCerebellum 59 weeks Female
SA150055LA_F8_CBCerebellum 59 weeks Female
SA150056LA_F6_CBCerebellum 59 weeks Female
SA150057LA_F3_CBCerebellum 59 weeks Female
SA150058LA_F5_CBCerebellum 59 weeks Female
SA150059LA_F2_CBCerebellum 59 weeks Female
SA150060LA_F1_CBCerebellum 59 weeks Female
SA150061LA_F4_CBCerebellum 59 weeks Female
SA150062LA_M7_CBCerebellum 59 weeks Male
SA150063LA_M6_CBCerebellum 59 weeks Male
SA150064LA_M8_CBCerebellum 59 weeks Male
SA150065LA_M1_CBCerebellum 59 weeks Male
SA150066LA_M5_CBCerebellum 59 weeks Male
SA150067LA_M3_CBCerebellum 59 weeks Male
SA150068LA_M2_CBCerebellum 59 weeks Male
SA150069LA_M4_CBCerebellum 59 weeks Male
SA150070EA_F6_CTCerebral cortex 16 weeks Female
SA150071EA_F7_CTCerebral cortex 16 weeks Female
SA150072EA_F5_CTCerebral cortex 16 weeks Female
SA150073EA_F2_CTCerebral cortex 16 weeks Female
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