Summary of Study ST001862

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001175. The data can be accessed directly via it's Project DOI: 10.21228/M8TM5F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001862
Study TitleCross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition
Study SummaryChild undernutrition is a global health issue associated with a high burden of infectious disease. Undernourished children display an overabundance of intestinal pathogens and pathobionts, and these bacteria induce enteric dysfunction in undernourished mice; however, the cause of their overgrowth remains poorly defined. Here, we show that disease-inducing human isolates of Enterobacteriaceae and Bacteroidales spp. are capable of multi-species symbiotic cross-feeding, resulting in synergistic growth of a mixed community in vitro. Growth synergy occurs uniquely under malnourished conditions limited in protein and iron: in this context, Bacteroidales spp. liberate diet- and mucin-derived sugars and Enterobacteriaceae spp. enhance the bioavailability of iron. Analysis of human microbiota datasets reveals that Bacteroidaceae and Enterobacteriaceae are strongly correlated in undernourished children, but not in adequately nourished children, consistent with a diet-dependent growth synergy in the human gut. Together these data suggest that dietary cross-feeding fuels the overgrowth of pathobionts in undernutrition.
Institute
University of British Columbia
DepartmentMichael Smith Laboratories
Last NameHuus
First NameKelsey
Address3125 East Mall
Emailkhuus@msl.ubc.ca
Phone+1-604-822-2210
Submit Date2021-07-11
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2021-11-06
Release Version1
Kelsey Huus Kelsey Huus
https://dx.doi.org/10.21228/M8TM5F
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Bacteria; Subject species: Bacteroides spp. and Escherichia spp. (mixed communities) (Factor headings shown in green)

mb_sample_id local_sample_id Factor
SA17437527_Blank30h
SA17437626_Blank20h
SA174377blank_media10h
SA174378blank_media20h
SA174379blank_media30h
SA17438025_Blank10h
SA17438128_Blank40h
SA174382BO5_16h16h
SA174383BO6_16h16h
SA174384E4_16h16h
SA17438509_E3-16h16h
SA174386B6_16h16h
SA17438701_B1-16h16h
SA174388B4_16h16h
SA174389B5_16h16h
SA174390E5_16h16h
SA174391E6_16h16h
SA17439204_BO1-16h16h
SA17439303_B3-16h16h
SA17439402_B2-16h16h
SA17439505_BO2-16h16h
SA174396BE6_16h16h
SA174397BE4_16h16h
SA174398BE5_16h16h
SA17439906_BO3-16h16h
SA174400BO4_16h16h
SA17440107_E1-16h16h
SA17440211_BE2-16h16h
SA17440312_BE3-16h16h
SA17440410_BE1-16h16h
SA17440508_E2-16h16h
SA174406E4_24h24h
SA174407BO6_24h24h
SA174408BO5_24h24h
SA174409E5_24h24h
SA174410BE5_24h24h
SA17441113_B1-24h24h
SA174412BE6_24h24h
SA174413BO4_24h24h
SA174414BE4_24h24h
SA174415E6_24h24h
SA174416B5_24h24h
SA17441721_E3-24h24h
SA17441820_E2-24h24h
SA17441922_BE1-24h24h
SA17442023_BE2-24h24h
SA17442124_BE3-24h24h
SA17442219_E1-24h24h
SA17442318_BO3-24h24h
SA17442414_B2-24h24h
SA174425B4_24h24h
SA17442615_B3-24h24h
SA17442716_BO1-24h24h
SA17442817_BO2-24h24h
SA174429B6_24h24h
Showing results 1 to 55 of 55
  logo