Summary of Study ST002066

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001308. The data can be accessed directly via it's Project DOI: 10.21228/M8N98X This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002066
Study TitleGlutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer
Study TypeBiomedical research
Study SummaryTo characterize the impact of KRAS co-mutations KEAP1 and STK11/Lkb1 on the metabolic and immune microenvironment of lung adenocarcinoma in immune-intact models, we generated a cohort of genetically engineered mouse models (GEMMs) to reflect the diverse tumor suppressor landscape seen in patients. Mice carrying the KrasG12D allele (K)21 were crossed with Keap1flox/flox (KK)22 and/or Lkb1flox/flox (KKL, KL)23 mice and genetic recombination induced by intranasal inhalation of Ad5-CMV-Cre adenovirus. We interrogated the metabolites present in lung tumor nodules collected from cohorts of KK, KL and KKL mice.
Institute
The Walter and Eliza Hall Institute of Medical Research
LaboratoryKate Sutherland
Last NameSarah
First NameBest
Address1G, Royal Parade, Parkville VIC 3052, Australia
Emailbest@wehi.edu.au
Phone+61-3-9345-2452
Submit Date2022-01-18
Num Groups5
Total Subjects25
Num Males17
Num Females8
Study CommentsL lobe of mice lung
PublicationsGlutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2022-05-02
Release Version1
Best Sarah Best Sarah
https://dx.doi.org/10.21228/M8N98X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id treatment
SA194269Blank_1Extraction blank
SA194270Blank_4Extraction blank
SA194271Blank_3Extraction blank
SA194272Blank_2Extraction blank
SA194273K_5Kras
SA194274K_4Kras
SA194275K_1Kras
SA194276K_2Kras
SA194277K_3Kras
SA194278KK_5Kras/Keap1
SA194279KK_4Kras/Keap1
SA194280KK_3Kras/Keap1
SA194281KK_2Kras/Keap1
SA194282KKL_5Kras/Keap1/Lkb1
SA194283KKL_4Kras/Keap1/Lkb1
SA194284KKL_3Kras/Keap1/Lkb1
SA194285KKL_1Kras/Keap1/Lkb1
SA194286KL_5Kras/Lkb1
SA194287KL_4Kras/Lkb1
SA194288KL_3Kras/Lkb1
SA194289KL_1Kras/Lkb1
SA194290KL_2Kras/Lkb1
SA194291KP_3Kras/p53
SA194292KP_4Kras/p53
SA194293KP_2Kras/p53
SA194294QC_4QC
SA194295QC_3QC
SA194296QC_2QC
SA194297QC_1QC
SA194299KK_1YFP(WT)/Kras/Keap1/p53(WT)
SA194298KP_1YFP(WT)/Kras/Keap1(WT)/p53
Showing results 1 to 31 of 31
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