Summary of Study ST002079

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001319. The data can be accessed directly via it's Project DOI: 10.21228/M87125 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002079
Study TitleDefining the mammalian coactivation of hepatic 12-hour clock and lipid metabolism
Study SummaryThe 12-hour clock coordinates lipid homeostasis, energy metabolism and stress rhythms via the transcriptional regulator XBP1. However, the biochemical and physiological basis for integrated control of the 12-hour clock and diverse metabolic pathways remains unclear. Here, we show that steroid receptor coactivator SRC-3 coactivates XBP1 transcription and regulates hepatic 12-hour cistrome and gene rhythmicity. Mice lacking SRC-3 show abnormal 12-hour rhythms in hepatic transcription, metabolic functions, systemic energetics, and rate-limiting lipid metabolic processes including triglyceride, phospholipid and cardiolipin pathways. Notably, 12-hour clock coactivation is not only preserved, with its cistromic activation priming ahead of the zeitgeber cue of light, but concomitant with rhythmic remodeling in the absence of food. These findings reveal that SRC-3 integrates the mammalian 12-hour clock, energy metabolism, and membrane and lipid homeostasis, and demonstrates a role for the 12-hour clock machinery as an active transcriptional mechanism in anticipating physiological and metabolic energy needs and stresses.
Institute
Baylor College of Medicine
Last NameMeng
First NameHuan
AddressOne Baylor Plaza BCM 130 Houston, TX 77030
Emailhuanm@bcm.edu
Phone5127729532
Submit Date2022-02-04
Num Groups12
Total Subjects24
Num Males24
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailOther
Release Date2022-02-22
Release Version1
Huan Meng Huan Meng
https://dx.doi.org/10.21228/M87125
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id ZT_time Genotype
SA196392SRC-3 KO ZT0 replicate2 posZT0 KO
SA196393SRC-3 KO ZT0 replicate1 posZT0 KO
SA196394SRC-3 KO ZT0 replicate1 negZT0 KO
SA196395SRC-3 KO ZT0 replicate2 negZT0 KO
SA196396SRC-3 WT ZT0 replicate1 posZT0 WT
SA196397SRC-3 WT ZT0 replicate2 negZT0 WT
SA196398SRC-3 WT ZT0 replicate1 negZT0 WT
SA196399SRC-3 WT ZT0 replicate2 posZT0 WT
SA196400SRC-3 KO ZT12 replicate2 posZT12 KO
SA196401SRC-3 KO ZT12 replicate2 negZT12 KO
SA196402SRC-3 KO ZT12 replicate1 posZT12 KO
SA196403SRC-3 KO ZT12 replicate1 negZT12 KO
SA196404SRC-3 WT ZT12 replicate1 negZT12 WT
SA196405SRC-3 WT ZT12 replicate1 posZT12 WT
SA196406SRC-3 WT ZT12 replicate2 posZT12 WT
SA196407SRC-3 WT ZT12 replicate2 negZT12 WT
SA196408SRC-3 KO ZT16 replicate2 posZT16 KO
SA196409SRC-3 KO ZT16 replicate1 posZT16 KO
SA196410SRC-3 KO ZT16 replicate1 negZT16 KO
SA196411SRC-3 KO ZT16 replicate2 negZT16 KO
SA196412SRC-3 WT ZT16 replicate2 negZT16 WT
SA196413SRC-3 WT ZT16 replicate1 posZT16 WT
SA196414SRC-3 WT ZT16 replicate2 posZT16 WT
SA196415SRC-3 WT ZT16 replicate1 negZT16 WT
SA196416SRC-3 KO ZT20 replicate1 negZT20 KO
SA196417SRC-3 KO ZT20 replicate1 posZT20 KO
SA196418SRC-3 KO ZT20 replicate2 negZT20 KO
SA196419SRC-3 KO ZT20 replicate2 posZT20 KO
SA196420SRC-3 WT ZT20 replicate2 posZT20 WT
SA196421SRC-3 WT ZT20 replicate1 posZT20 WT
SA196422SRC-3 WT ZT20 replicate2 negZT20 WT
SA196423SRC-3 WT ZT20 replicate1 negZT20 WT
SA196424SRC-3 KO ZT4 replicate2 negZT4 KO
SA196425SRC-3 KO ZT4 replicate1 posZT4 KO
SA196426SRC-3 KO ZT4 replicate1 negZT4 KO
SA196427SRC-3 KO ZT4 replicate2 posZT4 KO
SA196428SRC-3 WT ZT4 replicate1 negZT4 WT
SA196429SRC-3 WT ZT4 replicate2 negZT4 WT
SA196430SRC-3 WT ZT4 replicate2 posZT4 WT
SA196431SRC-3 WT ZT4 replicate1 posZT4 WT
SA196432SRC-3 KO ZT8 replicate1 posZT8 KO
SA196433SRC-3 KO ZT8 replicate2 posZT8 KO
SA196434SRC-3 KO ZT8 replicate2 negZT8 KO
SA196435SRC-3 KO ZT8 replicate1 negZT8 KO
SA196436SRC-3 WT ZT8 replicate1 negZT8 WT
SA196437SRC-3 WT ZT8 replicate2 posZT8 WT
SA196438SRC-3 WT ZT8 replicate1 posZT8 WT
SA196439SRC-3 WT ZT8 replicate2 negZT8 WT
Showing results 1 to 48 of 48
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