Summary of Study ST002252

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001440. The data can be accessed directly via it's Project DOI: 10.21228/M8KQ6P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002252
Study TitleLipidomics analysis on Arabidopsis autophagy mutants
Study SummaryAutophagy is an essential cellular process in eukaryotes that degrades and recycles macromolecules and organelles. Defects in autophagy is known to affect metabolism, including the lipidome. Genetic approaches have identified a series of AuTophaGy-related (ATG) genes in Arabidopsis. In this study we used WT (ecotype Col-0) and two Arabidopsis autophagy-defective mutants, atg7 and atg9 to perform a multi-omics study on the effect of nitrogen starvation treatment, which induces autophagy. Specifically, we have quantified ~100 lipids from leaf and root tissues of WT, atg7 and atg9 mutant plants, under either autophagy-inducing conditions (-N) or normal nitrogen conditions (+N). The lipid species we quantified include: DGDG, MGDG, LPC, LPE, PE, LPG, PC, PA, PG, PI, and PS. Our study sheds lights on the understanding of the relationships between autophagy and metabolism, especially lipid metabolism.
Institute
Iowa State University
DepartmentBiochemistry Biophysics, and Molecular Biology
LaboratoryNikolau Lab
Last NameDing
First NameGeng
Address2252 Molecular Biology BLDG, Pammel Drive
Emailgengding@iastate.edu
Phone515-294-0347
Submit Date2022-02-21
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailMS(Dir. Inf.)
Release Date2023-02-21
Release Version1
Geng Ding Geng Ding
https://dx.doi.org/10.21228/M8KQ6P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Plant; Subject species: Arabidopsis thaliana (Factor headings shown in green)

mb_sample_id local_sample_id Expeimental factors
SA216939sample72atg7-2 -N Leaf
SA216940sample60atg7-2 -N Leaf
SA216941sample84atg7-2 -N Leaf
SA216942sample36atg7-2 -N Leaf
SA216931sample34atg7-2 +N Leaf
SA216932sample58atg7-2 +N Leaf
SA216933sample70atg7-2 +N Leaf
SA216934sample82atg7-2 +N Leaf
SA216943sample83atg7-2 -N Root
SA216944sample59atg7-2 -N Root
SA216945sample35atg7-2 -N Root
SA216946sample71atg7-2 -N Root
SA216935sample69atg7-2 +N Root
SA216936sample57atg7-2 +N Root
SA216937sample33atg7-2 +N Root
SA216938sample81atg7-2 +N Root
SA216953sample32atg9-4 -N Leaf
SA216954sample80atg9-4 -N Leaf
SA216955sample56atg9-4 -N Leaf
SA216947sample54atg9-4 +N Leaf
SA216948sample78atg9-4 +N Leaf
SA216949sample30atg9-4 +N Leaf
SA216956sample55atg9-4 -N Root
SA216957sample31atg9-4 -N Root
SA216958sample79atg9-4 -N Root
SA216950sample53atg9-4 +N Root
SA216951sample29atg9-4 +N Root
SA216952sample77atg9-4 +N Root
SA216909QC11Quality control samples
SA216910QC07Quality control samples
SA216911QC09Quality control samples
SA216912QC08Quality control samples
SA216913QC06Quality control samples
SA216914QC10Quality control samples
SA216923sample76WT -N Leaf
SA216924sample64WT -N Leaf
SA216925sample52WT -N Leaf
SA216926sample28WT -N Leaf
SA216915sample50WT +N Leaf
SA216916sample62WT +N Leaf
SA216917sample26WT +N Leaf
SA216918sample74WT +N Leaf
SA216927sample27WT -N Root
SA216928sample63WT -N Root
SA216929sample75WT -N Root
SA216930sample51WT -N Root
SA216919sample49WT +N Root
SA216920sample25WT +N Root
SA216921sample61WT +N Root
SA216922sample73WT +N Root
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