Summary of Study ST002263
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001445. The data can be accessed directly via it's Project DOI: 10.21228/M8Z119 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002263 |
| Study Title | Intermittent fasting induces rapid hepatocyte proliferation to maintain the hepatostat |
| Study Summary | Nutrient availability fluctuates in most natural populations, forcing organisms to undergo periods of fasting and re-feeding. It is unknown how dietary change influences liver homeostasis. Here, we show that a switch from ad libitum feeding to intermittent fasting (IF) promotes rapid hepatocyte proliferation. Mechanistically, IF- induced hepatocyte proliferation is driven by the combined action of intestinally produced, systemic endocrine FGF15 and localized WNT signaling. IF proliferation re-establishes a constant liver-to-body-mass ratio during periods of fasting and re-feeding, a process termed the hepatostat. This study provides the first example of dietary influence on adult hepatocyte proliferation, and challenges the widely held view that liver tissue is mostly quiescent unless chemically or mechanically injured. |
| Institute | Stanford University |
| Last Name | DeFelice |
| First Name | Brian |
| Address | 1291 Welch Rd. |
| bcdefelice@ucdavis.edu | |
| Phone | 5303564485 |
| Submit Date | 2022-08-01 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML, raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-08-31 |
| Release Version | 1 |
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Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Genotype | Treatment |
|---|---|---|---|
| SA217390 | Klb_KO_AL_3 | Klb Knockout | ad libitum feeding |
| SA217391 | Klb_KO_AL_4 | Klb Knockout | ad libitum feeding |
| SA217392 | Klb_KO_AL_5 | Klb Knockout | ad libitum feeding |
| SA217393 | Klb_KO_AL_2 | Klb Knockout | ad libitum feeding |
| SA217394 | Klb_KO_IF_2 | Klb Knockout | intermittent fasting |
| SA217395 | Klb_KO_IF_5 | Klb Knockout | intermittent fasting |
| SA217396 | Klb_KO_IF_3 | Klb Knockout | intermittent fasting |
| SA217397 | Klb_KO_IF_4 | Klb Knockout | intermittent fasting |
| SA217398 | Tbx3_KO_AL_2 | Tbx3 Knockout | ad libitum feeding |
| SA217399 | Tbx3_KO_AL_1 | Tbx3 Knockout | ad libitum feeding |
| SA217400 | Tbx3_KO_AL_3 | Tbx3 Knockout | ad libitum feeding |
| SA217401 | Tbx3_KO_IF_3 | Tbx3 Knockout | intermittent fasting |
| SA217402 | Tbx3_KO_IF_4 | Tbx3 Knockout | intermittent fasting |
| SA217403 | Tbx3_KO_IF_1 | Tbx3 Knockout | intermittent fasting |
| SA217404 | Tbx3_KO_IF_2 | Tbx3 Knockout | intermittent fasting |
| SA217405 | AL_1 | Wild-type | ad libitum feeding |
| SA217406 | Al_3 | Wild-type | ad libitum feeding |
| SA217407 | AL_4 | Wild-type | ad libitum feeding |
| SA217408 | AL_2 | Wild-type | ad libitum feeding |
| SA217409 | IF_2 | Wild-type | intermittent fasting |
| SA217410 | IF_1 | Wild-type | intermittent fasting |
| SA217411 | IF_4 | Wild-type | intermittent fasting |
| SA217412 | IF_5 | Wild-type | intermittent fasting |
| Showing results 1 to 23 of 23 |
