Summary of Study ST002474

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001597. The data can be accessed directly via it's Project DOI: 10.21228/M88H9Z This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002474
Study TitleRetinol Dehydrogenase 10 Reduction Mediated Retinol Metabolism Disorder Promotes Diabetic Cardiomyopathy in Male Mice.
Study SummaryIn this study, we identify disordered cardiac retinol metabolism in type 2 diabetic male mice and patients characterized by retinol overload, all-trans retinoic acid deficiency. By supplementing type 2 diabetic male mice with retinol or all-trans retinoic acid, we demonstrate that both cardiac retinol overload and all-trans retinoic acid deficiency promote diabetic cardiomyopathy. Mechanistically, by constructing cardiomyocyte-specific conditional retinol dehydrogenase 10-knockout male mice and overexpressing retinol dehydrogenase 10 in male type 2 diabetic mice via adeno-associated virus, we verify that the reduction in cardiac retinol dehydrogenase 10 is the initiating factor for cardiac retinol metabolism disorder and results in diabetic cardiomyopathy. Therefore, we suggest that the reduction of cardiac retinol dehydrogenase 10 and its mediated disorder of cardiac retinol metabolism is a new mechanism underlying diabetic cardiomyopathy.
Institute
Zhongshan School of Medicine, Sun Yat-sen University
DepartmentDept. of Biochemistry
Last NameYandi
First NameWu
Address74, Zhongshan second street
Emailwuyd3@mail2.sysu.edu.cn
Phone15622158754
Submit Date2023-02-08
PublicationsRetinol Dehydrogenase 10 Reduction Mediated Retinol Metabolism Disorder Promotes Diabetic Cardiomyopathy in Male Mice.
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2023-02-13
Release Version1
Wu Yandi Wu Yandi
https://dx.doi.org/10.21228/M88H9Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Genotype Treatment
SA24779036-week db/db+aav9-RDH10-1db/db aav9-rdh10
SA24779136-week db/db+aav9-RDH10-2db/db aav9-rdh11
SA24779236-week db/db+aav9-RDH10-3db/db aav9-rdh12
SA24779336-week db/db+atRA-3db/db all-trans retinoic acid
SA24779436-week db/db+atRA-1db/db all-trans retinoic acid
SA24779536-week db/db+atRA-2db/db all-trans retinoic acid
SA24779636-week db/db-2db/db no
SA24779736-week db/db-3db/db no
SA24779832-week db/db-2db/db no
SA24779936-week db/db-1db/db no
SA24780032-week db/db-1db/db no
SA24780132-week db/db-6db/db no
SA24780232-week db/db-5db/db no
SA24780332-week db/db-4db/db no
SA24780432-week db/db-3db/db no
SA24780532-week db/db+Rol-1db/db retinol
SA24780632-week db/db+Rol-2db/db retinol
SA24780732-week db/db+Rol-3db/db retinol
SA24780832-week db/m-2db/m+ no
SA24780932-week db/m-3db/m+ no
SA24781032-week db/m-1db/m+ no
SA24781136-week db/m-1db/m+ no
SA24781236-week db/m-2db/m+ no
SA24781336-week db/m-3db/m+ no
SA247784RDH10-CKO-3"RDH10fl/fl, MYH6-iCre" tamoxifen
SA247785RDH10-CKO-2"RDH10fl/fl, MYH6-iCre" tamoxifen
SA247786RDH10-CKO-1"RDH10fl/fl, MYH6-iCre" tamoxifen
SA247787RDH10-FL-2RDH10fl/fl tamoxifen
SA247788RDH10-FL-1RDH10fl/fl tamoxifen
SA247789RDH10-FL-3RDH10fl/fl tamoxifen
Showing results 1 to 30 of 30
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