Summary of Study ST002500

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001614. The data can be accessed directly via it's Project DOI: 10.21228/M82T5P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002500
Study TitlePlasma metabolomic signatures from patients following high-dose total body irradiation
Study SummaryAlthough some progress has been made in the study of radiation injury, there are still no effective prevention and treatment methods for severe acute radiation syndrome or sickness (ARS). Accordingly, a thorough understanding of biological characteristics associated with high-dose radiation is essential for revealing the mechanisms underlying the varied biological processes following high dose radiation and the development of novel potent radioprotective agents. In present study, plasma metabolic characteristics were investigated from patients of hematopoietic stem cell transplantation following high-dose TBI pretreatment utilizing gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The most potential panel of four metabolic markers for radiation injury was selected and the metabolic disorders involved were explored. The metabolic disorders implied the dysregulation of gut microflora, shift of energy supply from aerobic respiration to ketogenesis, protein synthesis and metabolism in response to TBI. Although similar metabolic alternation patterns exist between male and female following high-dose irradiation, specific changes are observed in either male or female patients. These findings provide valuable information for further selecting biomarkers, clues of pathogenic mechanisms involved in high-dose radiation exposure.
Institute
Soochow University
Last NameWang
First NameChang
AddressSuzhou, No. 199, Renai Road, Suzhou Industrial Park
Emailwangchang@suda.edu.cn
Phone+8651265880067
Submit Date2023-02-27
Raw Data AvailableYes
Raw Data File Type(s)cdf, raw(Thermo)
Analysis Type DetailGC-MS/LC-MS
Release Date2024-02-28
Release Version1
Chang Wang Chang Wang
https://dx.doi.org/10.21228/M82T5P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA250400pos-Pre-TBI-28Control
SA250401pos-Pre-TBI-29Control
SA250402pos-Pre-TBI-30Control
SA250403pos-Pre-TBI-27Control
SA250404pos-Pre-TBI-26Control
SA250405pos-Pre-TBI-24Control
SA250406pos-Pre-TBI-25Control
SA250407pos-Pre-TBI-31Control
SA250408pos-Pre-TBI-32Control
SA250409pos-Pre-TBI-37Control
SA250410pos-Pre-TBI-38Control
SA250411neg-Pre-TBI-1Control
SA250412pos-Pre-TBI-36Control
SA250413pos-Pre-TBI-35Control
SA250414pos-Pre-TBI-33Control
SA250415pos-Pre-TBI-34Control
SA250416pos-Pre-TBI-23Control
SA250417pos-Pre-TBI-21Control
SA250418pos-Pre-TBI-9Control
SA250419pos-Pre-TBI-10Control
SA250420pos-Pre-TBI-11Control
SA250421pos-Pre-TBI-8Control
SA250422pos-Pre-TBI-7Control
SA250423pos-Pre-TBI-5Control
SA250424pos-Pre-TBI-6Control
SA250425pos-Pre-TBI-12Control
SA250426pos-Pre-TBI-13Control
SA250427pos-Pre-TBI-18Control
SA250428pos-Pre-TBI-19Control
SA250429pos-Pre-TBI-20Control
SA250430pos-Pre-TBI-17Control
SA250431pos-Pre-TBI-16Control
SA250432pos-Pre-TBI-14Control
SA250433pos-Pre-TBI-15Control
SA250434pos-Pre-TBI-22Control
SA250435GC-Pre-TBI-38Control
SA250436GC-Pre-TBI-15Control
SA250437GC-Pre-TBI-14Control
SA250438GC-Pre-TBI-13Control
SA250439GC-Pre-TBI-16Control
SA250440GC-Pre-TBI-17Control
SA250441GC-Pre-TBI-19Control
SA250442GC-Pre-TBI-18Control
SA250443GC-Pre-TBI-12Control
SA250444GC-Pre-TBI-11Control
SA250445GC-Pre-TBI-6Control
SA250446GC-Pre-TBI-5Control
SA250447GC-Pre-TBI-1Control
SA250448GC-Pre-TBI-7Control
SA250449GC-Pre-TBI-8Control
SA250450GC-Pre-TBI-10Control
SA250451GC-Pre-TBI-9Control
SA250452GC-Pre-TBI-20Control
SA250453GC-Pre-TBI-21Control
SA250454GC-Pre-TBI-33Control
SA250455GC-Pre-TBI-32Control
SA250456GC-Pre-TBI-31Control
SA250457GC-Pre-TBI-34Control
SA250458GC-Pre-TBI-35Control
SA250459GC-Pre-TBI-37Control
SA250460GC-Pre-TBI-36Control
SA250461GC-Pre-TBI-30Control
SA250462GC-Pre-TBI-29Control
SA250463GC-Pre-TBI-24Control
SA250464GC-Pre-TBI-23Control
SA250465GC-Pre-TBI-22Control
SA250466GC-Pre-TBI-25Control
SA250467GC-Pre-TBI-26Control
SA250468GC-Pre-TBI-28Control
SA250469GC-Pre-TBI-27Control
SA250470pos-Pre-TBI-2Control
SA250471pos-Pre-TBI-1Control
SA250472neg-Pre-TBI-27Control
SA250473neg-Pre-TBI-28Control
SA250474neg-Pre-TBI-29Control
SA250475neg-Pre-TBI-26Control
SA250476neg-Pre-TBI-25Control
SA250477neg-Pre-TBI-22Control
SA250478neg-Pre-TBI-23Control
SA250479neg-Pre-TBI-24Control
SA250480neg-Pre-TBI-30Control
SA250481neg-Pre-TBI-31Control
SA250482neg-Pre-TBI-36Control
SA250483neg-Pre-TBI-37Control
SA250484GC-Pre-TBI-2Control
SA250485neg-Pre-TBI-35Control
SA250486neg-Pre-TBI-34Control
SA250487neg-Pre-TBI-32Control
SA250488neg-Pre-TBI-33Control
SA250489neg-Pre-TBI-21Control
SA250490neg-Pre-TBI-20Control
SA250491neg-Pre-TBI-8Control
SA250492neg-Pre-TBI-9Control
SA250493neg-Pre-TBI-10Control
SA250494neg-Pre-TBI-7Control
SA250495neg-Pre-TBI-6Control
SA250496neg-Pre-TBI-2Control
SA250497neg-Pre-TBI-5Control
SA250498neg-Pre-TBI-11Control
SA250499neg-Pre-TBI-12Control
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