Summary of Study ST002817

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001748. The data can be accessed directly via it's Project DOI: 10.21228/M8RQ7M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002817
Study TitleInvestigation of metabolism in hypertrophic cardiomyopathy - Lipidomics
Study SummaryWe propose the use of targeted metabolomics to define the metabolic and molecular pathways altered in 2 mouse models (R92W-TnT and R403Q-MHC) of hypertrophic cardiomyopathy (HCM) that span the spectrum of human disease (heart failure and sudden death), with the goal of identifying treatment targets. Parallel targeted metabolomics studies will be performed in heart tissue and plasma at rest and following inotrope stimulation. Since energy compromise is expected to be most marked when the heart is subject to increased workload, as is the case during high-intensity exercise or inotropic stimulation, we propose metabolomics studies in heart tissue and plasma, at rest and following inotrope stimulation. We anticipate that the results of these studies will allow us to move forward with further investigations into specific metabolites of interest as biomarkers, to be tested in HCM patients in future studies.
Institute
University of California, San Francisco
DepartmentHypertrophic Cardiomyopathy Center of Excellence
LaboratoryUCSF Smith Cardiovascular Research Building
Last NameAbraham
First NameMaria Roselle
Address555 Mission Bay Boulevard South, San Francisco, CA 94158
EmailRoselle.Abraham@ucsf.edu
Phone415-502-3911
Submit Date2023-07-27
Num Groups2 groups of 2 (i.e., mutant vs control of two mouse models of HCM (R402Q-MyHC, R92W-TnT)
Total Subjects32
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2023-09-06
Release Version1
Maria Roselle Abraham Maria Roselle Abraham
https://dx.doi.org/10.21228/M8RQ7M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA302586M503Control MHC
SA302587M499Control MHC
SA302588M447Control MHC
SA302589M487Control MHC
SA302590M492Control MHC
SA302591M438Control MHC
SA302592M440Control MHC
SA302593M485Control MHC
SA302594T545Control TNT
SA302595T547Control TNT
SA302596T544Control TNT
SA302597T520Control TNT
SA302598T515Control TNT
SA302599T524Control TNT
SA302600T518Control TNT
SA302601T522Control TNT
SA302610MtdBlank004Method Blank
SA302611MtdBlank002Method Blank
SA302612MtdBlank005Method Blank
SA302613MtdBlank003Method Blank
SA302614MtdBlank007Method Blank
SA302615MtdBlank001Method Blank
SA302616MtdBlank008Method Blank
SA302617MtdBlank006Method Blank
SA302602M540MHC
SA302603M498MHC
SA302604M486MHC
SA302605M439MHC
SA302606M483MHC
SA302607M500MHC
SA302608M441MHC
SA302609M504MHC
SA302618Pool001Pool QC
SA302619Pool002Pool QC
SA302620Pool004Pool QC
SA302621Pool003Pool QC
SA302622Pool005Pool QC
SA302623Pool006Pool QC
SA302624Pool008Pool QC
SA302625Pool007Pool QC
SA302626Biorec001QC
SA302627Biorec002QC
SA302628Biorec006QC
SA302629Biorec005QC
SA302630Biorec007QC
SA302631Biorec008QC
SA302632Biorec003QC
SA302633Biorec004QC
SA302634T527TNT
SA302635T521TNT
SA302636T519TNT
SA302637T523TNT
SA302638T525TNT
SA302639T542TNT
SA302640T540TNT
SA302641T546TNT
Showing results 1 to 56 of 56
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