Summary of Study ST002868

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001791. The data can be accessed directly via it's Project DOI: 10.21228/M86M7M This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002868
Study TitlePathogenic Staphylococcus epidermidis ICE25 response to skin and blood pH
Study SummaryStaphylococcus epidermidis (SE) is one of the most common bacteria of the human skin microbiota. Despite its role as a commensal, SE has emerged as an opportunistic pathogen, associated with 80% of medical devices related infections. Moreover, these bacteria are extremely difficult to treat due to their ability to form biofilms and accumulate resistance to almost all classes of antimicrobials developed so far. Thus new preventive and therapeutic strategies are urgently needed. In spite of its clinical importance, the molecular mechanisms associated with SE colonisation and disease are still poorly understood. A deeper understanding of the metabolic and cellular processes associated with response to environmental factors characteristic of SE ecological niches in health and disease might provide new clues on colonisation and disease processes. Here we studied the impact of pH conditions, mimicking the skin pH (5.5) and blood pH (7.4), in a S. epidermidis pathogenic strain, belonging to the A/C clonal lineage, by means of next-generation proteomics and 1H NMR-based metabolomics. Moreover, we evaluated the metabolic changes occurring when a sudden pH change arise, simulating the skin barrier break produced by a catheter.
Institute
ITQB NOVA
Last NameGonçalves
First NameLuís G.
AddressAvenida Republica
Emaillgafeira@itqb.unl.pt
Phone214469464
Submit Date2023-09-13
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2024-01-02
Release Version1
Luís G. Gonçalves Luís G. Gonçalves
https://dx.doi.org/10.21228/M86M7M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Bacteria; Subject species: Staphylococcus epidermidis (Factor headings shown in green)

mb_sample_id local_sample_id Class
SA313040SE_a11_190712I55
SA313041SE_a07_190712I55
SA313042SE_a04_190712I55
SA313043SE_24_190530I55
SA313044SE_18_190530I55
SA313045SE_23_190530I55
SA313046SE_a18_190712I55
SA313047SE_a09_190712I57
SA313048SE_a13_190712_repI57
SA313049SE_a17_190712I57
SA313050SE_a03_190712I57
SA313051SE_7_190530I57
SA313052SE_4_190530I57
SA313053SE_10_190530I57
SA313054SE_11_190530I57
SA313055SE_a20_190712I77
SA313056SE_a16_190712I77
SA313057SE_a12_190712I77
SA313058SE_a06_190712I77
SA313059SE_9_190530I77
SA313060SE_6_190530I77
SA313061SE_1_190530I77
SA313062SE_5_190530I77
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