Summary of Study ST002878

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001761. The data can be accessed directly via it's Project DOI: 10.21228/M83139 This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002878
Study TitleAtlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy. Dynamic Labelling experiment.
Study SummaryMounting evidence supports an instructive role for metabolism in stem cell fate decisions. However, much is yet unknown about how fetal metabolism changes during mammalian development and how altered maternal metabolism shapes fetal metabolism. Here, we present a descriptive atlas of in vivo fetal murine metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using 13C-glucose and LC-MS, we profiled the metabolism of fetal brains, hearts, livers, and placentas harvested from pregnant dams between embryonic days (E)10.5 and 18.5. Comparative analysis of our large metabolomics dataset revealed metabolic features specific to fetal tissues developed under a hyperglycemic environment as well as metabolic signatures that may denote developmental transitions during euglycemic development. We observed sorbitol accumulation in fetal tissues and altered neurotransmitter levels in fetal brains isolated from dams with maternal hyperglycemia. Tracing 13C-glucose revealed disparate nutrient sourcing in fetuses depending on maternal glycemic states. Regardless of glycemic state, histidine-derived metabolites accumulated during late development in fetal tissues and maternal plasma. Our rich dataset presents a comprehensive overview of in vivo fetal tissue metabolism and alterations occurring as a result of maternal hyperglycemia.
University of California, Los Angeles
DepartmentBiological Chemistry
LaboratoryHeather Christofk
Last NameMatulionis
First NameNedas
Address615 Charles E Young Drive South Los Angeles, CA, 90095
Submit Date2023-09-25
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-12-08
Release Version1
Nedas Matulionis Nedas Matulionis application/zip

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Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Genotype U13C Glucose Labelling Timepoint
SA314499AK15-D8-S-01Akita 0 minutes
SA314500AK15-D4-S-01Akita 0 minutes
SA314501AK15-D10-S-01Akita 0 minutes
SA314502AK15-D9-H-01Akita 0 minutes
SA314503AK15-D9-S-01Akita 0 minutes
SA314504AK15-D9-B-01Akita 0 minutes
SA314505AK15-D9-L-01Akita 0 minutes
SA314506AK15-D9-P-01Akita 0 minutes
SA314507AK15-D4-P-01Akita 0 minutes
SA314508AK15-D9-H-03Akita 1 hour
SA314509AK15-D4-P-03Akita 1 hour
SA314510AK15-D9-P-03Akita 1 hour
SA314511AK15-D9-L-03Akita 1 hour
SA314512AK15-D4-S-03Akita 1 hour
SA314513AK15-D9-S-03Akita 1 hour
SA314514AK15-D8-S-03Akita 1 hour
SA314515AK15-D10-S-03Akita 1 hour
SA314516AK15-D9-B-03Akita 1 hour
SA314517AK15-D9-P-04Akita 2 hours
SA314518AK15-D9-S-04Akita 2 hours
SA314519AK15-D10-S-04Akita 2 hours
SA314520AK15-D9-H-04Akita 2 hours
SA314521AK15-D4-P-04Akita 2 hours
SA314522AK15-D9-L-04Akita 2 hours
SA314523AK15-D4-S-04Akita 2 hours
SA314524AK15-D9-B-04Akita 2 hours
SA314525AK15-D8-S-04Akita 2 hours
SA314535AK15-D4-P-02Akita 30 minutes
SA314536AK15-D9-B-02Akita 30 minutes
SA314537AK15-D10-S-02Akita 30 minutes
SA314538AK15-D9-L-02Akita 30 minutes
SA314539AK15-D9-P-02Akita 30 minutes
SA314540AK15-D4-S-02Akita 30 minutes
SA314541AK15-D8-S-02Akita 30 minutes
SA314542AK15-D9-H-02Akita 30 minutes
SA314543AK15-D9-S-02Akita 30 minutes
SA314526AK15-D9-H-05Akita 3 hours
SA314527AK15-D8-S-05Akita 3 hours
SA314528AK15-D4-S-05Akita 3 hours
SA314529AK15-D10-S-05Akita 3 hours
SA314530AK15-D9-P-05Akita 3 hours
SA314531AK15-D4-P-05Akita 3 hours
SA314532AK15-D9-B-05Akita 3 hours
SA314533AK15-D9-S-05Akita 3 hours
SA314534AK15-D9-L-05Akita 3 hours
SA314544AK15-D9-B-06Akita 4 hours
SA314545AK15-D9-H-06Akita 4 hours
SA314546AK15-D9-L-06Akita 4 hours
SA314547AK15-D9-S-06Akita 4 hours
SA314548AK15-D9-P-06Akita 4 hours
SA314549AK15-D4-P-06Akita 4 hours
SA314550AK15-D8-S-06Akita 4 hours
SA314551AK15-D4-S-06Akita 4 hours
SA314552WT15-D4-L-01Wild Type 0 minutes
SA314553WT15-D6-B-01Wild Type 0 minutes
SA314554WT15-D7-S-01Wild Type 0 minutes
SA314555WT15-D3-S-01Wild Type 0 minutes
SA314556WT15-D7-B-01Wild Type 0 minutes
SA314557WT15-D3-L-01Wild Type 0 minutes
SA314558WT15-D6-L-01Wild Type 0 minutes
SA314559WT15-D4-S-01Wild Type 0 minutes
SA314560WT15-D4-B-01Wild Type 0 minutes
SA314561WT15-D7-P-01Wild Type 0 minutes
SA314562WT15-D3-H-01Wild Type 0 minutes
SA314563WT15-D4-H-01Wild Type 0 minutes
SA314564WT15-D6-S-01Wild Type 0 minutes
SA314565WT15-D7-L-01Wild Type 0 minutes
SA314566WT15-D6-H-01Wild Type 0 minutes
SA314567WT15-D6-P-01Wild Type 0 minutes
SA314568WT15-D7-H-01Wild Type 0 minutes
SA314569WT15-D3-B-01Wild Type 0 minutes
SA314570WT15-D4-P-01Wild Type 0 minutes
SA314571WT15-D3-P-01Wild Type 0 minutes
SA314572WT15-D3-S-03Wild Type 1 hour
SA314573WT15-D7-S-03Wild Type 1 hour
SA314574WT15-D4-S-03Wild Type 1 hour
SA314575WT15-D4-P-03Wild Type 1 hour
SA314576WT15-D3-P-03Wild Type 1 hour
SA314577WT15-D6-P-03Wild Type 1 hour
SA314578WT15-D7-P-03Wild Type 1 hour
SA314579WT15-D6-S-03Wild Type 1 hour
SA314580WT15-D7-L-03Wild Type 1 hour
SA314581WT15-D4-H-03Wild Type 1 hour
SA314582WT15-D7-B-03Wild Type 1 hour
SA314583WT15-D3-L-03Wild Type 1 hour
SA314584WT15-D6-H-03Wild Type 1 hour
SA314585WT15-D4-L-03Wild Type 1 hour
SA314586WT15-D3-B-03Wild Type 1 hour
SA314587WT15-D6-B-03Wild Type 1 hour
SA314588WT15-D4-B-03Wild Type 1 hour
SA314589WT15-D6-L-03Wild Type 1 hour
SA314590WT15-D3-H-03Wild Type 1 hour
SA314591WT15-D7-H-03Wild Type 1 hour
SA314592WT15-D4-P-04Wild Type 2 hours
SA314593WT15-D7-B-04Wild Type 2 hours
SA314594WT15-D3-H-04Wild Type 2 hours
SA314595WT15-D6-P-04Wild Type 2 hours
SA314596WT15-D3-P-04Wild Type 2 hours
SA314597WT15-D7-H-04Wild Type 2 hours
SA314598WT15-D4-H-04Wild Type 2 hours
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