Summary of Study ST002922

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001814. The data can be accessed directly via it's Project DOI: 10.21228/M87D9M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002922
Study TitleEffects of DINCH and MINCH on adipocyte metabolism of human SGBS cells.
Study SummaryIn the first part of the project, we investigated the effects of DINCH and MINCH on central carbon metabolism. For this purpose, the human SGBS preadipocyte cell line (Wabitsch et al., 2001) was exposed to DINCH and MINCH at concentrations ranging from 10 nM to 10 µM and compared with cells differentiated with rosiglitazone (adipogenic reference) and without rosiglitazone (undifferentiated control). Analysis of central carbon metabolism showed that MINCH, similar to rosiglitazone, induces lipid accumulation mainly through PPARG-mediated upregulation of the pyruvate cycle. In addition, increased lactate production suggests altered glucose homeostasis induced by MINCH-treatment. Our results suggest that MINCH could potentially lead to a weight-promoting effect, as observed with thiazolidinediones, because of the similarity of the observed changes to the effects of the thiazolidinedione rosiglitazone.
Institute
Helmholtz Centre for Environmental Research
DepartmentMolecular Systems Biology
Last NameEngelmann
First NameBeatrice
AddressPermoserstraße 15, Leipzipg, Saxony, 03418, Germany
Emailbeatrice.engelmann@ufz.de
Phone00493412351099
Submit Date2023-10-04
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2023-11-03
Release Version1
Beatrice Engelmann Beatrice Engelmann
https://dx.doi.org/10.21228/M87D9M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA317308Ctrl_1Control
SA317309Ctrl_4Control
SA317310Ctrl_3Control
SA317311Ctrl_2Control
SA317312Ctrl_SN2Control supernatant
SA317313Ctrl_SN3Control supernatant
SA317314Ctrl_SN1Control supernatant
SA317315Ctrl_SN4Control supernatant
SA317316DINCH_100nM_2DINCH 100nM
SA317317DINCH_100nM_3DINCH 100nM
SA317318DINCH_100nM_1DINCH 100nM
SA317319DINCH_100nM_4DINCH 100nM
SA317320DINCH_100nM_SN3DINCH 100nM supernatant
SA317321DINCH_100nM_SN2DINCH 100nM supernatant
SA317322DINCH_100nM_SN1DINCH 100nM supernatant
SA317323DINCH_100nM_SN4DINCH 100nM supernatant
SA317332DINCH_10uM_2DINCH 10µM
SA317333DINCH_10uM_3DINCH 10µM
SA317334DINCH_10uM_4DINCH 10µM
SA317335DINCH_10uM_1DINCH 10µM
SA317336DINCH_10uM_SN1DINCH 10µM supernatant
SA317337DINCH_10uM_SN3DINCH 10µM supernatant
SA317338DINCH_10uM_SN2DINCH 10µM supernatant
SA317339DINCH_10uM_SN4DINCH 10µM supernatant
SA317324DINCH_10nM_2DINCH 10nM
SA317325DINCH_10nM_1DINCH 10nM
SA317326DINCH_10nM_3DINCH 10nM
SA317327DINCH_10nM_4DINCH 10nM
SA317328DINCH_10nM_SN3DINCH 10nM supernatant
SA317329DINCH_10nM_SN2DINCH 10nM supernatant
SA317330DINCH_10nM_SN4DINCH 10nM supernatant
SA317331DINCH_10nM_SN1DINCH 10nM supernatant
SA317340DINCH_1uM_2DINCH 1µM
SA317341DINCH_1uM_4DINCH 1µM
SA317342DINCH_1uM_3DINCH 1µM
SA317343DINCH_1uM_1DINCH 1µM
SA317344DINCH_1uM_SN3DINCH 1µM supernatant
SA317345DINCH_1uM_SN2DINCH 1µM supernatant
SA317346DINCH_1uM_SN4DINCH 1µM supernatant
SA317347DINCH_1uM_SN1DINCH 1µM supernatant
SA317384MINCH_10uM_blank3Medium blank supernatant
SA317385MINCH_10uM_blank2Medium blank supernatant
SA317386MINCH_10uM_blank1Medium blank supernatant
SA317348MINCH_100nM_4MINCH 100nM
SA317349MINCH_100nM_2MINCH 100nM
SA317350MINCH_100nM_1MINCH 100nM
SA317351MINCH_100nM_3MINCH 100nM
SA317352MINCH_100nM_SN4MINCH 100nM supernatant
SA317353MINCH_100nM_SN2MINCH 100nM supernatant
SA317354MINCH_100nM_SN3MINCH 100nM supernatant
SA317355MINCH_100nM_SN1MINCH 100nM supernatant
SA317364MINCH_10uM_2MINCH 10µM
SA317365MINCH_10uM_3MINCH 10µM
SA317366MINCH_10uM_4MINCH 10µM
SA317367MINCH_10uM_1MINCH 10µM
SA317368MINCH_10uM_SN2MINCH 10µM supernatant
SA317369MINCH_10uM_SN3MINCH 10µM supernatant
SA317370MINCH_10uM_SN4MINCH 10µM supernatant
SA317371MINCH_10uM_SN1MINCH 10µM supernatant
SA317356MINCH_10nM_3MINCH 10nM
SA317357MINCH_10nM_1MINCH 10nM
SA317358MINCH_10nM_4MINCH 10nM
SA317359MINCH_10nM_2MINCH 10nM
SA317360MINCH_10nM_SN3MINCH 10nM supernatant
SA317361MINCH_10nM_SN4MINCH 10nM supernatant
SA317362MINCH_10nM_SN2MINCH 10nM supernatant
SA317363MINCH_10nM_SN1MINCH 10nM supernatant
SA317372MINCH_1uM_4MINCH 1µM
SA317373MINCH_1uM_2MINCH 1µM
SA317374MINCH_1uM_1MINCH 1µM
SA317375MINCH_1uM_3MINCH 1µM
SA317376MINCH_1uM_SN4MINCH 1µM supernatant
SA317377MINCH_1uM_SN2MINCH 1µM supernatant
SA317378MINCH_1uM_SN3MINCH 1µM supernatant
SA317379MINCH_1uM_SN1MINCH 1µM supernatant
SA317380MINCH_GW_SN2MINCH GW supernatant
SA317381MINCH_GW_SN4MINCH GW supernatant
SA317382MINCH_GW_SN1MINCH GW supernatant
SA317383MINCH_GW_SN3MINCH GW supernatant
SA317387Rosi_4Rosiglitazone
SA317388Rosi_3Rosiglitazone
SA317389Rosi_2Rosiglitazone
SA317390Rosi_1Rosiglitazone
SA317391Rosi_SN1Rosiglitazone supernatant
SA317392Rosi_SN2Rosiglitazone supernatant
SA317393Rosi_SN3Rosiglitazone supernatant
SA317394Rosi_SN4Rosiglitazone supernatant
Showing results 1 to 87 of 87
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