Summary of Study ST002729

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001693. The data can be accessed directly via it's Project DOI: 10.21228/M8VT66 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002729
Study TitleImproved Endurance Capacity of Diabetic Mice during SGLT2 Inhibition: Potential Role of AICARP, an Endogenous AMPK Activator.
Study SummaryDiabetes is associated with an increased risk of deleterious changes in muscle mass and function or sarcopenia, leading to physical inactivity and worsening glycemic control. Given the negative energy balance during sodium-glucose cotransporter 2 (SGLT2) inhibition, whether SGLT2 inhibitors affect skeletal muscle mass and function is a matter of concern. However, how SGLT2 inhibition affects the skeletal muscle function in patients with diabetes remains insufficiently explored. We aimed to explore the effects of canagliflozin (CANA), an SGLT2 inhibitor, on skeletal muscles in genetically diabetic db/db mice.
Institute
Medical Institute of Bioregulation, Kyushu University
Last NameTakahashi
First NameMasatomo
AddressMaidashi 3-1-1, Higashi-ku, Fukuoka, Fukuoka, 8128582, Japan
Emailm-takahashi@bioreg.kyushu-u.ac.jp
Phone0926426171
Submit Date2023-05-25
Raw Data AvailableYes
Raw Data File Type(s)mzML, mzXML, lcd
Analysis Type DetailLC-MS
Release Date2023-11-09
Release Version1
Masatomo Takahashi Masatomo Takahashi
https://dx.doi.org/10.21228/M8VT66
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Combined analysis:

Analysis ID AN004423 AN004424 AN004425 AN004426
Analysis type MS MS MS MS
Chromatography type Ion exchange Reversed phase Reversed phase Normal phase
Chromatography system Thermo Dionex ICS-5000+ Shimadzu Nexera X2 Shimadzu Nexera X2 Shimadzu Nexera UC
Column Dionex IonPac AS11-HC (250 x 2mm,4um) Merck Discovery HS F5 (PFP) (150 x 2.1mm,3um) GL Sciences Inert Sustain C18 (150 × 2.1mm, 3um) Waters ACQUITY UPC2 Torus DEA (100 x 3.0mm, 1.7um)
MS Type ESI ESI ESI ESI
MS instrument type Orbitrap Orbitrap Orbitrap Triple quadrupole
MS instrument name Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap Shimadzu LCMS-8060
Ion Mode UNSPECIFIED UNSPECIFIED POSITIVE UNSPECIFIED
Units relative peak area relative peak area concentration (pmol/mg-protein) relative peak area

MS:

MS ID:MS004170
Analysis ID:AN004423
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:MS acquisition: FullMS (posi/nega) Data processing/software: Reifycs Cascade ver. 1.0
Ion Mode:UNSPECIFIED
  
MS ID:MS004171
Analysis ID:AN004424
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:MS acquisition: FullMS (posi/nega) Data processing/software: Reifycs Cascade ver. 1.0
Ion Mode:UNSPECIFIED
  
MS ID:MS004172
Analysis ID:AN004425
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:MS acquisition: FullMS (posi) Data processing/software: Reifycs Cascade ver. 1.0
Ion Mode:POSITIVE
  
MS ID:MS004173
Analysis ID:AN004426
Instrument Name:Shimadzu LCMS-8060
Instrument Type:Triple quadrupole
MS Type:ESI
MS Comments:MS acquisition: MRM mode (posi/nega) Data processing/software: Multi-ChromatoAnalyst (mCAT) ver.23
Ion Mode:UNSPECIFIED
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