Summary of Study ST002765
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001723. The data can be accessed directly via it's Project DOI: 10.21228/M80F0C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002765 |
| Study Title | Disorder of Lipids Induced by Gestational Asthma and its Effect on the Development of Fetal Lung Function and Fetal Health |
| Study Summary | Maternal asthma during pregnancy is highly correlated with fetal growth and development, and can cause damage to both the mother and fetus, but the underlying mechanisms are not yet clear. Amniotic fluid, as the environment for fetal growth and development, may be affected by lipid metabolism disorders, which can impact fetal lung function development. A rat model of asthma during pregnancy induced by common allergen house dust mite (HDM) was used to investigate changes in lipid composition in amniotic fluid and bronchoalveolar lavage fluid (BALF) by ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS), revealing the impact of maternal asthma during pregnancy on fetal lipid metabolism. In this study, maternal asthma aggravated inflammatory indicators and pathological manifestations after fetal allergen exposure, creating a high oxidative stress growth environment for the fetus, and causing metabolic differences in various lipid groups, including phosphatidylethanolamine (PE), phosphatidylglycerol (PG), and fatty acids (FA), indicating significant lipid metabolism disorders. Improving lipid metabolism may help asthmatic pregnant women maintain healthy fetal development. |
| Institute | Nanjing University of Chinese Medicine |
| Last Name | Fang |
| First Name | Huafeng |
| Address | No.138 xianlin road, nanjing city, Nanjing, China, 210046, China |
| Riorofhf@outlook.com | |
| Phone | +86 18852416998 |
| Submit Date | 2023-06-29 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-01-01 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN004500 | AN004501 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | Reversed phase | Reversed phase |
| Chromatography system | Thermo UltiMate 3000 RS | Thermo UltiMate 3000 RS |
| Column | Waters Acquity UPLC CSH C18 column (100 mm×2.1mm, 1.7 m) | Waters Acquity UPLC CSH C18 column (100 mm×2.1mm, 1.7 m) |
| MS Type | ESI | ESI |
| MS instrument type | Other | Other |
| MS instrument name | Thermo Q Exactive Orbitrap | Thermo Q Exactive Orbitrap |
| Ion Mode | POSITIVE | NEGATIVE |
| Units | Peak area | Peak area |
MS:
| MS ID: | MS004247 |
| Analysis ID: | AN004500 |
| Instrument Name: | Thermo Q Exactive Orbitrap |
| Instrument Type: | Other |
| MS Type: | ESI |
| MS Comments: | Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer was used for both positive and negative ion modes. Parameters of mass spectrometry: spray voltage was 3.5 kV (positive) and 3.0 kV (negative); for both ionization modes, sheath gas, aux gas, capillary temperature, and heater temperature were maintained at 35 arb, 15 arb, 325 °C and 300 °C, respectively; scan range was m/z 215–1800. |
| Ion Mode: | POSITIVE |
| MS ID: | MS004248 |
| Analysis ID: | AN004501 |
| Instrument Name: | Thermo Q Exactive Orbitrap |
| Instrument Type: | Other |
| MS Type: | ESI |
| MS Comments: | Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer was used for both positive and negative ion modes. Parameters of mass spectrometry: spray voltage was 3.5 kV (positive) and 3.0 kV (negative); for both ionization modes, sheath gas, aux gas, capillary temperature, and heater temperature were maintained at 35 arb, 15 arb, 325 °C and 300 °C, respectively; scan range was m/z 215–1800. |
| Ion Mode: | NEGATIVE |
