Summary of Study ST003066
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001912. The data can be accessed directly via it's Project DOI: 10.21228/M8KB0M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST003066 |
| Study Title | Heritability of RBC metabolites: baseline correlation of metabolites and markers of RBC health and stability |
| Study Summary | The goal of this study was to examine the genetic heritability of metabolites and to identify metabolites, present immediately after blood draw, that were highly correlated with red blood cells (RBCs) ex vivo survival. Extreme longevity in humans is known to be a heritable trait. In a well-established twin erythrocyte metabolomics and proteomics database, we identified the longevity factor spermidine and a cluster of correlated molecules with high heritability estimates. Erythrocyte spermidine is 82% heritable and significantly correlated with 59 metabolites and 22 proteins. Thirty-eight metabolites and 19 proteins were >20% heritable, with a mean heritability of 61% for metabolites and 49% for proteins. Correlated metabolites are concentrated in energy metabolism, redox homeostasis, and autophagy pathways. Erythrocyte mean cell volume (MCV)−an established heritable trait−was consistently negatively correlated with the top 25 biomolecules most strongly correlated with spermidine, indicating that smaller MCVs are associated with higher concentrations of spermidine and correlated molecules. |
| Institute | University of Iowa |
| Last Name | Raife |
| First Name | Thomas |
| Address | 1685 Highland Ave. Madison WI 53705 |
| traife@wisc.edu | |
| Phone | (608)-265-8492 |
| Submit Date | 2024-02-02 |
| Analysis Type Detail | Other |
| Release Date | 2024-02-28 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN005022 |
|---|---|
| Analysis type | MS |
| Chromatography type | Combined GC/LC |
| Chromatography system | Thermo-Finnigan Trace DSQ (GC); Waters Acquity (LC) |
| Column | Combined GC/LC |
| MS Type | Other |
| MS instrument type | Other |
| MS instrument name | Thermo Velos LTQ Orbitrap; Thermo Trace DSQ |
| Ion Mode | UNSPECIFIED |
| Units | area under curve |
MS:
| MS ID: | MS004761 |
| Analysis ID: | AN005022 |
| Instrument Name: | Thermo Velos LTQ Orbitrap; Thermo Trace DSQ |
| Instrument Type: | Other |
| MS Type: | Other |
| MS Comments: | Combined GC/LC analysis. Results not separable into GC and LC data. |
| Ion Mode: | UNSPECIFIED |
| Analysis Protocol File: | Instrumentation_details.txt |
