Summary of Study ST001813
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001146. The data can be accessed directly via it's Project DOI: 10.21228/M8K69N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001813 |
| Study Title | Associations between the gut microbiome and metabolome in early life |
| Study Type | Untargeted and semi-targeted metabolomics analysis |
| Study Summary | The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function (using untargeted (binned) NMR and relative concentration data) in order to characterize the taxa-function relationship in early life. |
| Institute | University of North Carolina at Chapel Hill |
| Department | Nutrition |
| Laboratory | Metabolomics and Exposome Laboratory at UNC CH Nutrition Research Institute |
| Last Name | Sumner |
| First Name | Susan |
| Address | 500 Laureate Way, Kannapolis, NC, 28081, USA |
| susan_sumner@unc.edu | |
| Phone | 919-541-6861 |
| Submit Date | 2021-05-26 |
| Total Subjects | 440 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2021-07-14 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
NMR:
| NMR ID: | NM000206 |
| Analysis ID: | AN002939 |
| Instrument Name: | Avance III 700 MHz NMR Spectrometer |
| Instrument Type: | FT-NMR |
| NMR Experiment Type: | 1D-1H |
| Field Frequency Lock: | 3015 Hz, D2O |
| Standard Concentration: | 0.5 mM |
| Spectrometer Frequency: | 700 MHz |
| NMR Probe: | CP QCI/HPCN |
| NMR Solvent: | 90% H2O, 10% D2O |
| NMR Tube Size: | 5 mm |
| Shimming Method: | topshim |
| Pulse Sequence: | noesygppr1d |
| Water Suppression: | pre-saturation |
| Pulse Width: | 14.59 us |
| Power Level: | 12.3 Watts |
| Receiver Gain: | 36 |
| Offset Frequency: | 3290.61 Hz |
| Presaturation Power Level: | 0.0000964 Watts |
| Chemical Shift Ref Cpd: | DSS-d6 |
| Temperature: | 25 C |
| Number Of Scans: | 64 |
| Dummy Scans: | 4 |
| Acquisition Time: | 3.9 seconds |
| Relaxation Delay: | 2 seconds |
| Spectral Width: | 12 ppm |
| Num Data Points Acquired: | 65536 |
| Real Data Points: | 32768 |
| Line Broadening: | 0.5 Hz |
| Zero Filling: | Yes |
| Apodization: | Lorentzian |
| Baseline Correction Method: | Polynomial |
| Chemical Shift Ref Std: | DSS-d6 |
| Binned Increment: | 0.04ppm |
| Binned Data Excluded Range: | 4.79 - 4.85 ppm (Water region) |
