Summary of Study ST001813
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001146. The data can be accessed directly via it's Project DOI: 10.21228/M8K69N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001813 |
| Study Title | Associations between the gut microbiome and metabolome in early life |
| Study Type | Untargeted and semi-targeted metabolomics analysis |
| Study Summary | The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function (using untargeted (binned) NMR and relative concentration data) in order to characterize the taxa-function relationship in early life. |
| Institute | University of North Carolina at Chapel Hill |
| Department | Nutrition |
| Laboratory | Metabolomics and Exposome Laboratory at UNC CH Nutrition Research Institute |
| Last Name | Sumner |
| First Name | Susan |
| Address | 500 Laureate Way, Kannapolis, NC, 28081, USA |
| susan_sumner@unc.edu | |
| Phone | 919-541-6861 |
| Submit Date | 2021-05-26 |
| Total Subjects | 440 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2021-07-14 |
| Release Version | 1 |
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Project:
| Project ID: | PR001146 |
| Project DOI: | doi: 10.21228/M8K69N |
| Project Title: | Associations between the gut microbiome and metabolome in early life |
| Project Type: | Metabolomics Analysis |
| Project Summary: | Broad spectrum NMR metabolomics data was acquired from feces collected from infants at age 6 weeks (n=158) and 1 year (n=282) of life who are enrolled in the New Hampshire Birth Cohort. NMR binned data (untargeted) and relative concentration data (semi-targeted) were integrated with these subject’s microbiome data using statistical and machine learning-based methods to characterize the taxa-function relationship in early life. |
| Institute: | Dartmouth College |
| Department: | Department of Epidemiology |
| Last Name: | Karagas |
| First Name: | Margaret |
| Address: | One Medical Center Road, 7927 HB, Rubin Building, Lebanon, NH 03756, USA |
| Email: | Margaret.Karagas@Dartmouth.edu |
| Phone: | 603-653-9010 |
| Funding Source: | National Institutes of Health (grants NLM R01LM012723, NIGMS P20GM104416, NCI P30CA023108, NCI R21CA253408, NLM K01LM012426, NIH UG3 OD023275, NIEHS P01ES022832 and EPA RD-83544201) |
| Project Comments: | For further details, contact Margaret Karagass for information on the New Hampshire Birth Cohort Study |
