Summary of Study ST002536
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001632. The data can be accessed directly via it's Project DOI: 10.21228/M8RB05 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002536 |
| Study Title | Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma |
| Study Type | comparison of tumor versus normal tissue |
| Study Summary | With the goal of performing RNA-seq and metabolomic profiling, a cohort of fresh frozen oncocytic (Hürthle cell) thyroid carcinoma (HCC) samples was established with confirmation of mtDNA mutation status and chromosomal copy number. This cohort contained 24 oncocytic (Hürthle cell) tumors with 18 cases having matched normal thyroid tissue. Tumor samples included 21 primary tumors comprised of 19 HCC (8 widely invasive, 11 minimally invasive) and 2 oncocytic (Hürthle cell) adenomas as well as 2 locoregional recurrences (LR) and 1 distant metastasis (DM). HCC samples were collected and stored as part of the Mass General Brigham Institutional Review Board (protocol number 2008P001466). Frozen tissue was accessed to create the cohort used in the study. |
| Institute | Broad Institute of MIT and Harvard |
| Department | Metabolomics Platform |
| Last Name | Clish |
| First Name | Clary |
| Address | 415 Main Street, Cambridge, MA, 02142, USA |
| clary@broadinstitute.org | |
| Phone | 617-714-7654 |
| Submit Date | 2023-03-30 |
| Num Groups | 2 |
| Total Subjects | tumors from 24 subjects and matched normal tissue from a subset of 18 subjects |
| Num Males | N/A |
| Num Females | N/A |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-04-17 |
| Release Version | 1 |
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Project:
| Project ID: | PR001632 |
| Project DOI: | doi: 10.21228/M8RB05 |
| Project Title: | Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma |
| Project Summary: | Oncocytic (Hürthle cell) carcinoma of the thyroid (HCC) is genetically characterized by complex I mitochondrial DNA mutations and widespread chromosomal losses. In this project, RNA-seq and metabolomics were used to identify candidate molecular effectors activated by these genetic drivers. |
| Institute: | Broad Institute of MIT and Harvard |
| Department: | Metabolomics Platform |
| Last Name: | Clish |
| First Name: | Clary |
| Address: | 415 Main Street, Cambridge, MA, 02142, USA |
| Email: | clary@broadinstitute.org |
| Phone: | 617-714-7654 |
| Funding Source: | Inflammatory Bowel Disease Grant DK043351, Boston Area Diabetes and Endocrinology Research Center (BADERC) Award DK057521, the Bertarelli Rare Cancers Fund, the Elizabeth and Michael Ruane family, 2T32DK007028-46, NIH K00CA212468, NIH K12CA087723, and the Howard Hughes Medical Institute |
| Publications: | submitted |
| Contributors: | Raj K. Gopal, Venkata R. Vantaku, Apekshya Panda, Bryn Reimer, Sneha Rath, Tsz-Leung To, Adam S. Fisch, Murat Cetinbas, Maia Livneh, Michael J. Calcaterra, Benjamin J. Gigliotti, Kerry Pierce, Clary B. Clish, Dora Dias-Santagata, Peter M. Sadow, Lori J. Wirth, Gilbert H. Daniels, Ruslan I. Sadreyev, Sarah E. Calvo, Sareh Parangi, Vamsi K. Mootha |
