Summary of Study ST002568
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001655. The data can be accessed directly via it's Project DOI: 10.21228/M8S726 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002568 |
| Study Title | Assessment of metabolic changes in different animal models of maladaptive right ventricular hypertrophy in chronic pulmonary hypertension by lipidomics and HILIC |
| Study Summary | We analyzed plasma samples from 33 Yucatan pigs belonging to four different experimental models of pulmonary hypertension (PH): M1 chronic postcapillary PH by pulmonary vein banding; M2 chronic PH by aorto-pulmonary shunting; M3: right ventricular pressure overload by pulmonary artery banding, thus without PH; and M0 sham procedure. Briefly, blood samples were collected 8 months after surgery and untargeted lipidomics and HILIC metabolomic analyses were performed for negative and positive polarities. For quality control, 5 QC samples were included in each analysis, iterative MSMS was performed for metabolite annotation. Plasma metabolomic patterns differed among groups, displaying arginine-nitric oxide and histidine deficiency in both PH models (M1 and M2), altered taurine and purine pathways in M2, and lipidomic changes in all three models of pressure overload. |
| Institute | Universidad CEU San Pablo |
| Last Name | Moran |
| First Name | Maria |
| Address | Universidad CEU-San Pablo. Urb. Montepríncipe |
| maria.morangarrido@ceu.es | |
| Phone | 913724769 |
| Submit Date | 2023-03-23 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-05-10 |
| Release Version | 1 |
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Project:
| Project ID: | PR001655 |
| Project DOI: | doi: 10.21228/M8S726 |
| Project Title: | Pulmonary hypertension metabolomics |
| Project Summary: | Identify relevant mechanisms associated to maladaptive right ventricular hypertrophy in pulmonary hypertension, beyond pressure overload, through the integration of advanced imaging and omics. |
| Institute: | Universidad CEU San Pablo |
| Last Name: | Moran |
| First Name: | Maria |
| Address: | Universidad CEU-San Pablo. Urb. Montepríncipe |
| Email: | maria.morangarrido@ceu.es |
| Phone: | 913724769 |
