Summary of Study ST002997

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001867. The data can be accessed directly via it's Project DOI: 10.21228/M8CX3R This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study ID	ST002997
Study Title	Metabolomic analysis reveal mechanisms of Shenzao dripping pill against myocardial ischemia
Study Type	Metabolomic analysis on serum samples of SZDP against MI
Study Summary	This study employed the advanced Ultra-high performance liquid chromatography-quadruple-Exactive Orbitrap mass spectrometry technology to detect biomarkers related to myocardial ischemia in rats. Additionally, it aimed to investigate the effect of the Shenzao dripping pill on rectifying metabolic disorders and preserving the metabolites in dynamic balance during myocardial ischemia, analyze potential metabolic pathways, and elucidate the mechanism of action of SZDP through the lens of metabolomics.
Institute	Guangdong Pharmaceutical University
Department	Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province
Laboratory	Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine
Last Name	Kuang
First Name	Jiehui
Address	Waihuan East Road, 280, Guangzhou, Guangdong, 510006, China
Email	kuang_jieh@163.com
Phone	(020)-222-3333
Submit Date	2023-12-04
Raw Data Available	Yes
Raw Data File Type(s)	mzML, raw(Thermo)
Analysis Type Detail	LC-MS
Release Date	2023-12-21
Release Version	1

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Sample Preparation:

Sampleprep ID:	SP003116
Sampleprep Summary:	In each 200 μL aliquot of serum sample, 600 μL of acetonitrile was added and the mixture was thoroughly mixed for a duration of 1 minute. Then, the mixture was subjected to centrifugation at 13000 rpm and 4 °C for a period of 15 min. The supernatant was collected and evaporated to dryness with nitrogen. Methanol (100 μL) was added, and the reconstituted mixture was vortexed and centrifuged at 13000 rpm and a temperature of 4 °C for 15 min.

Sampleprep ID:

SP003116

Sampleprep Summary:

In each 200 μL aliquot of serum sample, 600 μL of acetonitrile was added and the mixture was thoroughly mixed for a duration of 1 minute. Then, the mixture was subjected to centrifugation at 13000 rpm and 4 °C for a period of 15 min. The supernatant was collected and evaporated to dryness with nitrogen. Methanol (100 μL) was added, and the reconstituted mixture was vortexed and centrifuged at 13000 rpm and a temperature of 4 °C for 15 min.