Summary of Study ST001749

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001121. The data can be accessed directly via it's Project DOI: 10.21228/M8SX23 This work is supported by NIH grant, U2C- DK119886.


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Study IDST001749
Study TitleREACH Metabolomics Study
Study SummaryIncreasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. This study utilized blood samples of 23 asymptomatic late middle-aged adults with familial and genetic risk for AD who underwent 26 weeks of supervised treadmill training. Metabolomic profiles were evaluated using MS.
University of Wisconsin - Madison
LaboratoryWisconsin Alzheimer's Disease Research Center
Last NameGaitán
First NameJulian
Address600 Highland Ave. J5/1M CSC MC2420, Madison, WI 53792
Submit Date2021-04-15
Num Groups2
Total Subjects23
Num Males12
Num Females11
Analysis Type DetailLC-MS
Release Date2021-05-11
Release Version1
Julian Gaitán Julian Gaitán application/zip

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Treatment ID:TR001839
Treatment Summary:Participants were randomized after baseline assessment to either Usual Physical Activity (UPA) or Enhanced Physical Activity (EPA) using 1:1 block randomization accounting for age and sex. UPA group was given educational material about maintaining a healthy and active lifestyle. The EPA group engaged in a supervised, progressive, moderate-to-vigorous intensity aerobic exercise training program three times per week for 50 minutes per session from week seven through 26.