Summary of Study ST001749

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001121. The data can be accessed directly via it's Project DOI: 10.21228/M8SX23 This work is supported by NIH grant, U2C- DK119886.

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Study ID	ST001749
Study Title	REACH Metabolomics Study
Study Summary	Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. This study utilized blood samples of 23 asymptomatic late middle-aged adults with familial and genetic risk for AD who underwent 26 weeks of supervised treadmill training. Metabolomic profiles were evaluated using MS.
Institute	University of Wisconsin - Madison
Department	Medicine
Laboratory	Wisconsin Alzheimer's Disease Research Center
Last Name	Gaitán
First Name	Julian
Address	600 Highland Ave. J5/1M CSC MC2420, Madison, WI 53792
Email	jgaitan@medicine.wisc.edu
Phone	608-263-2245
Submit Date	2021-04-15
Num Groups	2
Total Subjects	23
Num Males	12
Num Females	11
Analysis Type Detail	LC-MS
Release Date	2021-05-11
Release Version	1

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Treatment:

Treatment ID:	TR001839
Treatment Summary:	Participants were randomized after baseline assessment to either Usual Physical Activity (UPA) or Enhanced Physical Activity (EPA) using 1:1 block randomization accounting for age and sex. UPA group was given educational material about maintaining a healthy and active lifestyle. The EPA group engaged in a supervised, progressive, moderate-to-vigorous intensity aerobic exercise training program three times per week for 50 minutes per session from week seven through 26.

Treatment ID:

TR001839

Treatment Summary:

Participants were randomized after baseline assessment to either Usual Physical Activity (UPA) or Enhanced Physical Activity (EPA) using 1:1 block randomization accounting for age and sex. UPA group was given educational material about maintaining a healthy and active lifestyle. The EPA group engaged in a supervised, progressive, moderate-to-vigorous intensity aerobic exercise training program three times per week for 50 minutes per session from week seven through 26.