Summary of Study ST002075

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001315. The data can be accessed directly via it's Project DOI: 10.21228/M8R11F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002075
Study Title	Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device (Part 2)
Study Summary	15 Subjects were sampled using ingestible sampling device. Device sampled regions of the small intestine depending on design of sampling device.
Institute	University of California, Davis
Last Name	Folz
First Name	Jacob
Address	451 Health Sciences Drive
Email	jfolz@ucdavis.edu
Phone	(530) 752-8129
Submit Date	2022-02-02
Raw Data Available	Yes
Raw Data File Type(s)	raw(Thermo)
Analysis Type Detail	LC-MS
Release Date	2022-12-15
Release Version	1

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Treatment:

Treatment ID:	TR002170
Treatment Summary:	The capsule sampling device (CapScan®, Envivo Bio Inc, San Carlos CA) consists of a one-way valve capping a hollow elastic bladder. The device is prepared for packaging by evacuating the elastic bladder, folding it in half, and packaging the folded device inside a dissolvable capsule measuring 6.5 mm in diameter×23 mm long, onto which an enteric coating is applied. The target pH was pH 6 for type 1 and type 2 capsules, and pH 7.5 for type 3 and type 4, with type 2 and type 4 having a thicker coating to result in delayed opening. The elastic bladder then unfolds and expands into a tube 6 mm in diameter and 33 mm long, thereby drawing in ~300 µL of gut luminal contents through the one-way valve. The one-way valve maintains the integrity of the sample collected inside the bladder as the device moves through the colon and is exposed to stool.

Treatment ID:

TR002170

Treatment Summary:

The capsule sampling device (CapScan®, Envivo Bio Inc, San Carlos CA) consists of a one-way valve capping a hollow elastic bladder. The device is prepared for packaging by evacuating the elastic bladder, folding it in half, and packaging the folded device inside a dissolvable capsule measuring 6.5 mm in diameter×23 mm long, onto which an enteric coating is applied. The target pH was pH 6 for type 1 and type 2 capsules, and pH 7.5 for type 3 and type 4, with type 2 and type 4 having a thicker coating to result in delayed opening. The elastic bladder then unfolds and expands into a tube 6 mm in diameter and 33 mm long, thereby drawing in ~300 µL of gut luminal contents through the one-way valve. The one-way valve maintains the integrity of the sample collected inside the bladder as the device moves through the colon and is exposed to stool.