Summary of Study ST002212

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001413. The data can be accessed directly via it's Project DOI: 10.21228/M82X3Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002212
Study Title	Human fecal metabolome profiles under 3 different dietary terms
Study Summary	The gut microbiota produce numerous metabolites that affect host physiology, although the effects of the daily diet on human intestinal metabolome profiles and robustness are not well understood. Here we investigated the robustness of the human intestinal environment through gut microbiome and metabolome profiles in response to daily dietary fluctuations. We analyzed 176 fecal samples from 25 healthy Japanese individuals under three dietary conditions, including heterogeneous and homogeneous diets. Human intestinal metabolome and microbiome profiles were unique to each individual and were robust under daily dietary fluctuation in most cases. Our findings provide insight into the use of intestinal environment information for clinical studies.
Institute	Keio University
Department	Institute for Advanced Biosciences
Last Name	Fukuda
First Name	Shinji
Address	Kakuganji 246-2, Mizukami, Tsuruoka City Yamagata,Japan
Email	sfukuda@sfc.keio.ac.jp
Phone	+81-235-29-800
Submit Date	2022-06-29
Raw Data Available	Yes
Raw Data File Type(s)	OTHER
Analysis Type Detail	LC-MS
Release Date	2023-07-28
Release Version	1

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Treatment:

Treatment ID:	TR002310
Treatment Summary:	Human fecal metabolome profiles under 3 different dietary terms. During the first phase (term 1), there was no restriction on diet, but consumption of medicinal drugs and dietary supplements were prohibited. In the second phase (term 2), subjects ate provided meals. The menus of meals were different every time. For the last phase (term 3), subjects continuously ate an identical meal 15 times, three times a day over 5 days. Commercially available box meals, frozen foods, fruits, sandwiches, rice balls, retort foods were provided in term 2 and 3. Throughout the trial, subjects collected their feces and froze them as soon as they could. After which, the frozen fecal samples were shipped frozen to the Institute for Advanced Biosciences, Keio University, Yamagata, Japan, for metabolome and metagenome analysis.

Treatment ID:

TR002310

Treatment Summary:

Human fecal metabolome profiles under 3 different dietary terms. During the first phase (term 1), there was no restriction on diet, but consumption of medicinal drugs and dietary supplements were prohibited. In the second phase (term 2), subjects ate provided meals. The menus of meals were different every time. For the last phase (term 3), subjects continuously ate an identical meal 15 times, three times a day over 5 days. Commercially available box meals, frozen foods, fruits, sandwiches, rice balls, retort foods were provided in term 2 and 3. Throughout the trial, subjects collected their feces and froze them as soon as they could. After which, the frozen fecal samples were shipped frozen to the Institute for Advanced Biosciences, Keio University, Yamagata, Japan, for metabolome and metagenome analysis.