Summary of Study ST002522
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001624. The data can be accessed directly via it's Project DOI: 10.21228/M8S99J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002522 |
| Study Title | Lipidomics study on the effect of LBP protein on hepatic lipid composition in mice |
| Study Summary | Stress elevates the formation of ROS and lipid peroxidation, which induce lipid droplets (LDs) accumulation and adverse metabolic disturbance. Here, we explored the novel role of Lipopolysaccharide-binding protein (LBP) as an anti-oxidant, which can capture unsaturated triglyceride (TG) into LDs to avoid lipid peroxidation. Oxidative stress upregulates LBP level and promotes LDs growth via the LBP/TG phase transition. Upon N-Acetyl-L-cysteine (NAC) elimination of ROS, LBP is exported from LD along with PRDX4, resulting in an increase in phospholipid synthesis. Chronic stress causes LBP upregulation and leads to obesity, which can be rescued by NAC treatment in vivo. These results support that LBP maintains homeostasis by coupling lipid metabolism and redox signal, which provides insights into redox medicine that mitigate stress-induced metabolic dysfunction. Hepatic lipidomics in overexpressed LBP and WT mice treated with NAC after 24h fasting |
| Institute | University of Science and Technology of China |
| Department | Department of Endocrinology and Laboratory for Diabetes |
| Laboratory | The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine |
| Last Name | Zhang |
| First Name | Qilun |
| Address | Lujiang road no.17 |
| zql66666@mail.ustc.edu.cn | |
| Phone | +8618356507293 |
| Submit Date | 2023-03-21 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-03-21 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR002634 |
| Treatment Summary: | WT and LBPKI/KI mice were fed with normal diet(ND) and high-fat diet(HFD) for 16 weeks respectively. WT mice were fasted for 24 hours or treated with NAC for 3h after a 24-hour fast. |
